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Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults
Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults
Background Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Aim and methods Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.

Results: The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB=-33.12+0.675*LDL+11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937))

Conclusion: Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.
1475-2840
55
Cho, Dong-Sik
2cc68652-5a8e-4fec-aee9-a82a0dd8fe29
Woo, Sookyoung
16534302-9779-4802-b5ad-a4319f71196e
Kim, Seonwoo
93f05474-1867-47c3-92d0-0f353b427642
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Sung, Ki-Chul
a4318faa-ffbe-4206-b7aa-285768065c01
Kong, Joon-Hyuk
b88076f2-a448-4014-8ce4-d8a2d54b71b2
Cho, Dong-Sik
2cc68652-5a8e-4fec-aee9-a82a0dd8fe29
Woo, Sookyoung
16534302-9779-4802-b5ad-a4319f71196e
Kim, Seonwoo
93f05474-1867-47c3-92d0-0f353b427642
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Sung, Ki-Chul
a4318faa-ffbe-4206-b7aa-285768065c01
Kong, Joon-Hyuk
b88076f2-a448-4014-8ce4-d8a2d54b71b2

Cho, Dong-Sik, Woo, Sookyoung, Kim, Seonwoo, Byrne, Christopher D., Sung, Ki-Chul and Kong, Joon-Hyuk (2012) Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults. Cardiovascular Diabetology, 11 (1), 55. (doi:10.1186/1475-2840-11-55). (PMID:22607125)

Record type: Article

Abstract

Background Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Aim and methods Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.

Results: The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB=-33.12+0.675*LDL+11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937))

Conclusion: Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.

Full text not available from this repository.

More information

Published date: 18 May 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 340714
URI: https://eprints.soton.ac.uk/id/eprint/340714
ISSN: 1475-2840
PURE UUID: 50c6b501-b2da-43cf-bbdd-8caf61985bc9
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 29 Jun 2012 15:27
Last modified: 06 Jun 2018 12:54

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