The University of Southampton
University of Southampton Institutional Repository

Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Cho, Dong-Sik, Woo, Sookyoung, Kim, Seonwoo, Byrne, Christopher D., Sung, Ki-Chul and Kong, Joon-Hyuk (2012) Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults Cardiovascular Diabetology, 11, (1), p. 55. (doi:10.1186/1475-2840-11-55). (PMID:22607125).

Record type: Article

Abstract

Background Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Aim and methods Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.

Results: The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB=-33.12+0.675*LDL+11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937))

Conclusion: Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.

Full text not available from this repository.

More information

Published date: 18 May 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 340714
URI: http://eprints.soton.ac.uk/id/eprint/340714
ISSN: 1475-2840
PURE UUID: 50c6b501-b2da-43cf-bbdd-8caf61985bc9

Catalogue record

Date deposited: 29 Jun 2012 15:27
Last modified: 18 Jul 2017 05:42

Export record

Altmetrics

Contributors

Author: Dong-Sik Cho
Author: Sookyoung Woo
Author: Seonwoo Kim
Author: Ki-Chul Sung
Author: Joon-Hyuk Kong

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×