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Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Cho, Dong-Sik, Woo, Sookyoung, Kim, Seonwoo, Byrne, Christopher D., Sung, Ki-Chul and Kong, Joon-Hyuk (2012) Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults Cardiovascular Diabetology, 11, (1), p. 55. (doi:10.1186/1475-2840-11-55). (PMID:22607125).

Record type: Article


Background Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Aim and methods Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.

Results: The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB=-33.12+0.675*LDL+11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937))

Conclusion: Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.

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Published date: 18 May 2012
Organisations: Human Development & Health


Local EPrints ID: 340714
ISSN: 1475-2840
PURE UUID: 50c6b501-b2da-43cf-bbdd-8caf61985bc9

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Date deposited: 29 Jun 2012 15:27
Last modified: 18 Jul 2017 05:42

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Author: Dong-Sik Cho
Author: Sookyoung Woo
Author: Seonwoo Kim
Author: Ki-Chul Sung
Author: Joon-Hyuk Kong

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