Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes
Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes
Background: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.
Objective: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.
Methods: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.
Results: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.
Conclusions: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.
950-956
Pike, Katharine C.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Pike, Katharine C.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Pike, Katharine C., Inskip, Hazel M., Robinson, Sian, Lucas, Jane S., Cooper, Cyrus, Harvey, Nicholas C., Godfrey, Keith M. and Roberts, Graham
(2012)
Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes.
Thorax, 67 (11), .
(doi:10.1136/thoraxjnl-2012-201888).
(PMID:22707522)
Abstract
Background: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.
Objective: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.
Methods: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.
Results: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.
Conclusions: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.
This record has no associated files available for download.
More information
e-pub ahead of print date: 15 June 2012
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 340831
URI: http://eprints.soton.ac.uk/id/eprint/340831
ISSN: 0040-6376
PURE UUID: dce6b7ff-89dd-4ed5-8e3b-d1592ce64dea
Catalogue record
Date deposited: 04 Jul 2012 10:15
Last modified: 18 Mar 2024 03:01
Export record
Altmetrics
Contributors
Author:
Katharine C. Pike
Author:
Sian Robinson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics