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Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes

Record type: Article

Background: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.

Objective: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.

Methods: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.

Results: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.

Conclusions: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.

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Citation

Pike, Katharine C., Inskip, Hazel M., Robinson, Sian, Lucas, Jane S., Cooper, Cyrus, Harvey, Nicholas C., Godfrey, Keith M. and Roberts, Graham (2012) Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes Thorax, 67, (11), pp. 950-956. (doi:10.1136/thoraxjnl-2012-201888). (PMID:22707522).

More information

e-pub ahead of print date: 15 June 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 340831
URI: http://eprints.soton.ac.uk/id/eprint/340831
ISSN: 0040-6376
PURE UUID: dce6b7ff-89dd-4ed5-8e3b-d1592ce64dea
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Sian Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 04 Jul 2012 10:15
Last modified: 18 Jul 2017 05:41

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Contributors

Author: Katharine C. Pike
Author: Hazel M. Inskip ORCID iD
Author: Sian Robinson ORCID iD
Author: Jane S. Lucas
Author: Cyrus Cooper
Author: Graham Roberts

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