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Stratified medicine for cancer therapy

Record type: Article

As knowledge of the biological processes underlying malignant transformation becomes increasingly sophisticated, apparently similar diseases can be redefined according to the critical disrupted biological pathways and networks. The key genetic changes in most cancers can be mapped to one of a relatively few pathways, making it possible to classify tumours by their abnormal pathways and to identify potentially treatable--'druggable'--targets within these. The aim of the stratified approach to cancer therapy is to improve the effectiveness, tolerability and affordability of novel therapeutic agents.

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Citation

Shaw, Emily C. and Johnson, Peter W. M. (2012) Stratified medicine for cancer therapy Drug Discovery Today, 17, (5-6), pp. 261-268. (doi:10.1016/j.drudis.2012.02.004). (PMID:22493785).

More information

Published date: March 2012
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 340835
URI: http://eprints.soton.ac.uk/id/eprint/340835
ISSN: 1359-6446
PURE UUID: fd2010e9-d666-4fc4-87d0-b3d941bae224
ORCID for Peter W. M. Johnson: ORCID iD orcid.org/0000-0003-2306-4974

Catalogue record

Date deposited: 03 Jul 2012 15:11
Last modified: 18 Jul 2017 05:41

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Contributors

Author: Emily C. Shaw

University divisions


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