Chemically modified siRNA: tools and applications

Watts, Jonathan K., Deleavey, Glen F. and Damha, Masad J. (2008) Chemically modified siRNA: tools and applications. Drug Discovery Today, 13 (19/20), 842-855. (doi:10.1016/j.drudis.2008.05.007).

Record type: Article

Abstract

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.

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Published date: October 2008

Identifiers

Local EPrints ID: 340893

URI: http://eprints.soton.ac.uk/id/eprint/340893

DOI: doi:10.1016/j.drudis.2008.05.007

ISSN: 1359-6446

PURE UUID: 66adea8a-cbb6-4a79-9622-109751391291

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Date deposited: 06 Jul 2012 09:52

Last modified: 14 Mar 2024 11:31

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Contributors

Author: Jonathan K. Watts

Author: Glen F. Deleavey

Author: Masad J. Damha

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