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Chemically modified siRNA: tools and applications

Chemically modified siRNA: tools and applications
Chemically modified siRNA: tools and applications
Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.
1359-6446
842-855
Watts, Jonathan K.
c4de85ee-aaa3-4e7d-99b3-147a4de4f01c
Deleavey, Glen F.
dda67f51-5175-47ae-b793-f7e06b729974
Damha, Masad J.
31a9645e-2a72-4cc5-aa35-b82a16f1d535
Watts, Jonathan K.
c4de85ee-aaa3-4e7d-99b3-147a4de4f01c
Deleavey, Glen F.
dda67f51-5175-47ae-b793-f7e06b729974
Damha, Masad J.
31a9645e-2a72-4cc5-aa35-b82a16f1d535

Watts, Jonathan K., Deleavey, Glen F. and Damha, Masad J. (2008) Chemically modified siRNA: tools and applications. Drug Discovery Today, 13 (19/20), 842-855. (doi:10.1016/j.drudis.2008.05.007).

Record type: Article

Abstract

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.

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2008_Watts_siRNA_review_-_DDT.pdf - Version of Record
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Published date: October 2008

Identifiers

Local EPrints ID: 340893
URI: http://eprints.soton.ac.uk/id/eprint/340893
ISSN: 1359-6446
PURE UUID: 66adea8a-cbb6-4a79-9622-109751391291

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Date deposited: 06 Jul 2012 09:52
Last modified: 14 Mar 2024 11:31

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Contributors

Author: Jonathan K. Watts
Author: Glen F. Deleavey
Author: Masad J. Damha

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