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Graphical modeling can be used to illustrate associations between variables describing functioning in head and neck cancer patients

Graphical modeling can be used to illustrate associations between variables describing functioning in head and neck cancer patients
Graphical modeling can be used to illustrate associations between variables describing functioning in head and neck cancer patients
Objective: To examine the associations between variables of functioning measured by the International Classification of Functioning, Disability and Health (ICF) in head and neck cancer (HNC) patients by means of graphical modeling.

Study design and setting: Graphical modeling was used on a data set of a cross-sectional multicentric study of 145 patients with HNC. Functioning was qualified using the extended ICF checklist. Multiple imputation was used to handle missing data. The least absolute shrinkage and selection operator for generalized linear models was used to identify conditional associations between the ICF categories. Bootstrap aggregating was used to enhance the accuracy and validity of model selection.

Results: The resulting graph shows largely meaningful associations between the ICF categories. One central point could be visualized consisting of a circular path of d330 Speaking, d350 Conversation, b510 Ingestion functions, s320 Structure of mouth, and b310 Voice functions. Another important structure in the graph were the bow-shaped associations beginning with d335 Producing nonverbal messages to b130 Energy and drive functions.

Conclusion: Graphical modeling can be used to describe associations between different areas of functioning in HNC patients. They found associations can be the basis for improved rehabilitation and gives a deeper understanding of functioning in HNC patients.
tumor, head and neck cancer, graphical models, functioning, international classification of functioning disability and health (icf), rehabilitation
885-892
Becker, Sven
634e54de-9b25-4845-b808-de8e1cfdb1e2
Strobi, Ralf
c1e9d344-ea52-46ca-b01a-d838f0b20c00
Cieza, Alarcos
a0df25c5-ee2c-4580-82b3-d0a75591580e
Grill, Eva
859ba1e1-b539-46c1-b644-237f3add6814
Harréus, Ulrich
f3dab1a8-2fa2-4bf3-b60d-6a94aa64ed4d
Tschiesner, Uta
ed8dc63b-bb54-4124-a57a-92e22167a144
Becker, Sven
634e54de-9b25-4845-b808-de8e1cfdb1e2
Strobi, Ralf
c1e9d344-ea52-46ca-b01a-d838f0b20c00
Cieza, Alarcos
a0df25c5-ee2c-4580-82b3-d0a75591580e
Grill, Eva
859ba1e1-b539-46c1-b644-237f3add6814
Harréus, Ulrich
f3dab1a8-2fa2-4bf3-b60d-6a94aa64ed4d
Tschiesner, Uta
ed8dc63b-bb54-4124-a57a-92e22167a144

Becker, Sven, Strobi, Ralf, Cieza, Alarcos, Grill, Eva, Harréus, Ulrich and Tschiesner, Uta (2011) Graphical modeling can be used to illustrate associations between variables describing functioning in head and neck cancer patients. Journal of Clinical Epidemiology, 64 (8), 885-892. (doi:10.1016/j.jclinepi.2010.11.010). (PMID:21316921)

Record type: Article

Abstract

Objective: To examine the associations between variables of functioning measured by the International Classification of Functioning, Disability and Health (ICF) in head and neck cancer (HNC) patients by means of graphical modeling.

Study design and setting: Graphical modeling was used on a data set of a cross-sectional multicentric study of 145 patients with HNC. Functioning was qualified using the extended ICF checklist. Multiple imputation was used to handle missing data. The least absolute shrinkage and selection operator for generalized linear models was used to identify conditional associations between the ICF categories. Bootstrap aggregating was used to enhance the accuracy and validity of model selection.

Results: The resulting graph shows largely meaningful associations between the ICF categories. One central point could be visualized consisting of a circular path of d330 Speaking, d350 Conversation, b510 Ingestion functions, s320 Structure of mouth, and b310 Voice functions. Another important structure in the graph were the bow-shaped associations beginning with d335 Producing nonverbal messages to b130 Energy and drive functions.

Conclusion: Graphical modeling can be used to describe associations between different areas of functioning in HNC patients. They found associations can be the basis for improved rehabilitation and gives a deeper understanding of functioning in HNC patients.

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More information

e-pub ahead of print date: 12 February 2011
Published date: August 2011
Keywords: tumor, head and neck cancer, graphical models, functioning, international classification of functioning disability and health (icf), rehabilitation
Organisations: Psychology

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Local EPrints ID: 340991
URI: https://eprints.soton.ac.uk/id/eprint/340991
PURE UUID: 590a75c5-5e69-4f0d-9327-9c9e016151c0

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Date deposited: 10 Jul 2012 09:18
Last modified: 18 Jul 2017 05:39

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