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Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease
Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.

0040-6376
380-384
Krauss-Etschmann, S.
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Bush, A.
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Bellusci, S.
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Brusselle, G. G.
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Erik K Dahlen, S.
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Dehmel, S.
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Eickelberg, O.
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Gibson, G.
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Hylkema, M. N.
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Knaus, P.
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Konigshoff, M.
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Lloyd, C. M.
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Macciarini, P.
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Mailleux, A.
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Marsland, B. J.
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Postma, D. S.
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Roberts, G.
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Samakovlis, C.
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Stocks, J.
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Vandesompele, J.
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Wjst, M.
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Holloway, J.
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Krauss-Etschmann, S.
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Bush, A.
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Bellusci, S.
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Brusselle, G. G.
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Erik K Dahlen, S.
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Dehmel, S.
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Eickelberg, O.
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Gibson, G.
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Hylkema, M. N.
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Knaus, P.
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Konigshoff, M.
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Lloyd, C. M.
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Macciarini, P.
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Mailleux, A.
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Marsland, B. J.
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Postma, D. S.
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Roberts, G.
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Samakovlis, C.
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Stocks, J.
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Vandesompele, J.
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Wjst, M.
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Holloway, J.
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Krauss-Etschmann, S., Bush, A., Bellusci, S., Brusselle, G. G., Erik K Dahlen, S., Dehmel, S., Eickelberg, O., Gibson, G., Hylkema, M. N., Knaus, P., Konigshoff, M., Lloyd, C. M., Macciarini, P., Mailleux, A., Marsland, B. J., Postma, D. S., Roberts, G., Samakovlis, C., Stocks, J., Vandesompele, J., Wjst, M. and Holloway, J. (2013) Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax, 68 (4), 380-384. (doi:10.1136/thoraxjnl-2012-201902).

Record type: Article

Abstract

Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.

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More information

Accepted/In Press date: 10 July 2012
Published date: April 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 341077
URI: http://eprints.soton.ac.uk/id/eprint/341077
ISSN: 0040-6376
PURE UUID: 7f0013a5-8f1c-4d5a-906a-64ea1dfcd8df
ORCID for J. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 12 Jul 2012 16:17
Last modified: 28 Apr 2022 01:42

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Contributors

Author: S. Krauss-Etschmann
Author: A. Bush
Author: S. Bellusci
Author: G. G. Brusselle
Author: S. Erik K Dahlen
Author: S. Dehmel
Author: O. Eickelberg
Author: G. Gibson
Author: M. N. Hylkema
Author: P. Knaus
Author: M. Konigshoff
Author: C. M. Lloyd
Author: P. Macciarini
Author: A. Mailleux
Author: B. J. Marsland
Author: D. S. Postma
Author: G. Roberts
Author: C. Samakovlis
Author: J. Stocks
Author: J. Vandesompele
Author: M. Wjst
Author: J. Holloway ORCID iD

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