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Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges

Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges
Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges
A novel microfluidic concentration gradient generator is designed where secondary flow, induced via a surface groove, is used to yield a concentration gradient across the output of the microfluidic device. The concentration gradient generator design consists of a single microfluidic channel with two inputs and a single obliquely angled surface groove within the base of the channel to induce the secondary flow and create the concentration gradient. The design allows a concentration gradient to be chosen, either linear or exponential, at the exit of the microfluidic channel with the shape and dimensions of the surface groove within the channel obtained by numerical optimisation. The designed device has a small footprint, suitable for integration within lab-on-a-chip structures for the delivery of a series of an agent to either (i) a single channel and with a concentration gradient or to (ii) a series of reactors with concentrations across a defined range, for bioscience or pharmaceutical screening applications or for chemical reactions.
mixing, microchannel, numerical simulation, concentration gradient, laminar flow
1385-8947
296-303
Friedrich, Daniel
38fec5ed-5104-4d67-9354-2e064d0bdad2
Please, Colin P.
118dffe7-4b38-4787-a972-9feec535839e
Melvin, Tracy
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
Friedrich, Daniel
38fec5ed-5104-4d67-9354-2e064d0bdad2
Please, Colin P.
118dffe7-4b38-4787-a972-9feec535839e
Melvin, Tracy
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f

Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2012) Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges. Chemical Engineering Journal, 193-194, 296-303. (doi:10.1016/j.cej.2012.04.041).

Record type: Article

Abstract

A novel microfluidic concentration gradient generator is designed where secondary flow, induced via a surface groove, is used to yield a concentration gradient across the output of the microfluidic device. The concentration gradient generator design consists of a single microfluidic channel with two inputs and a single obliquely angled surface groove within the base of the channel to induce the secondary flow and create the concentration gradient. The design allows a concentration gradient to be chosen, either linear or exponential, at the exit of the microfluidic channel with the shape and dimensions of the surface groove within the channel obtained by numerical optimisation. The designed device has a small footprint, suitable for integration within lab-on-a-chip structures for the delivery of a series of an agent to either (i) a single channel and with a concentration gradient or to (ii) a series of reactors with concentrations across a defined range, for bioscience or pharmaceutical screening applications or for chemical reactions.

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More information

Published date: 15 June 2012
Keywords: mixing, microchannel, numerical simulation, concentration gradient, laminar flow
Organisations: Optoelectronics Research Centre, Mathematical Sciences

Identifiers

Local EPrints ID: 341152
URI: http://eprints.soton.ac.uk/id/eprint/341152
ISSN: 1385-8947
PURE UUID: 0b5ef631-5945-4853-8318-eff9f1c48521

Catalogue record

Date deposited: 16 Jul 2012 15:15
Last modified: 12 Aug 2019 16:31

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Contributors

Author: Daniel Friedrich
Author: Colin P. Please
Author: Tracy Melvin

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