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Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges

Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2012) Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges Chemical Engineering Journal, 193-194, pp. 296-303. (doi:10.1016/j.cej.2012.04.041).

Record type: Article


A novel microfluidic concentration gradient generator is designed where secondary flow, induced via a surface groove, is used to yield a concentration gradient across the output of the microfluidic device. The concentration gradient generator design consists of a single microfluidic channel with two inputs and a single obliquely angled surface groove within the base of the channel to induce the secondary flow and create the concentration gradient. The design allows a concentration gradient to be chosen, either linear or exponential, at the exit of the microfluidic channel with the shape and dimensions of the surface groove within the channel obtained by numerical optimisation. The designed device has a small footprint, suitable for integration within lab-on-a-chip structures for the delivery of a series of an agent to either (i) a single channel and with a concentration gradient or to (ii) a series of reactors with concentrations across a defined range, for bioscience or pharmaceutical screening applications or for chemical reactions.

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Published date: 15 June 2012
Keywords: mixing, microchannel, numerical simulation, concentration gradient, laminar flow
Organisations: Optoelectronics Research Centre, Mathematical Sciences


Local EPrints ID: 341152
ISSN: 1385-8947
PURE UUID: 0b5ef631-5945-4853-8318-eff9f1c48521

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Date deposited: 16 Jul 2012 15:15
Last modified: 18 Jul 2017 05:38

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Author: Daniel Friedrich
Author: Colin P. Please
Author: Tracy Melvin

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