The University of Southampton
University of Southampton Institutional Repository

Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges

Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2012) Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges Chemical Engineering Journal, 193-194, pp. 296-303. (doi:10.1016/j.cej.2012.04.041).

Record type: Article

Abstract

A novel microfluidic concentration gradient generator is designed where secondary flow, induced via a surface groove, is used to yield a concentration gradient across the output of the microfluidic device. The concentration gradient generator design consists of a single microfluidic channel with two inputs and a single obliquely angled surface groove within the base of the channel to induce the secondary flow and create the concentration gradient. The design allows a concentration gradient to be chosen, either linear or exponential, at the exit of the microfluidic channel with the shape and dimensions of the surface groove within the channel obtained by numerical optimisation. The designed device has a small footprint, suitable for integration within lab-on-a-chip structures for the delivery of a series of an agent to either (i) a single channel and with a concentration gradient or to (ii) a series of reactors with concentrations across a defined range, for bioscience or pharmaceutical screening applications or for chemical reactions.

Full text not available from this repository.

More information

Published date: 15 June 2012
Keywords: mixing, microchannel, numerical simulation, concentration gradient, laminar flow
Organisations: Optoelectronics Research Centre, Mathematical Sciences

Identifiers

Local EPrints ID: 341152
URI: http://eprints.soton.ac.uk/id/eprint/341152
ISSN: 1385-8947
PURE UUID: 0b5ef631-5945-4853-8318-eff9f1c48521

Catalogue record

Date deposited: 16 Jul 2012 15:15
Last modified: 18 Jul 2017 05:38

Export record

Altmetrics

Contributors

Author: Daniel Friedrich
Author: Colin P. Please
Author: Tracy Melvin

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×