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Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive of reduced TTFT (P < .001) and overall survival (P = .002). Multivariate analysis confirmed that high Ang2 was an independent prognosticator for TTFT (hazard ratio = 1.739; 95% confidence interval, 1.059-2.857; P = .029). Significant associations were found between high Ang2 and advanced Binet stages (P < .001), high beta(2)-microglobulin (P < .001), unmutated variable region of immunoglobulin heavy chain gene status (P < .001), high CD38 and zeta-chain-associated protein kinase 70 expression (P < .001 and P = .003), and intermediate/high cytogenetic risk (P = .005). Moreover, Ang2 added prognostic power to other conventional prognosticators and helped to refine prognosis among CLL subsets with both high and low vascular endothelial growth factor plasma levels. Ang2 plasma level may be a useful independent prognosticator for CLL.
0006-4971
584-592
Maffei, Rossana
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Martinelli, Silvia
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Santachiara, Rita
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Rossi, Davide
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Guarnotta, Carla
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Sozzi, Elisa
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Zucchetto, Antonella
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Rigolin, Gian Matteo
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Fiorcari, Stefania
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Castelli, Ilaria
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Fontana, Marcella
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Coluccio, Valeria
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Leonardi, Giovanna
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Zucchini, Patrizia
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Tripodo, Claudio
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Cuneo, Antonio
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Gattei, Valter
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Del Poeta, Giovanni
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Forconi, Francesco
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Gaidano, Gianluca
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Torelli, Giuseppe
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Marasca, Roberto
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Maffei, Rossana
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Martinelli, Silvia
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Santachiara, Rita
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Rossi, Davide
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Guarnotta, Carla
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Sozzi, Elisa
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Zucchetto, Antonella
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Rigolin, Gian Matteo
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Fiorcari, Stefania
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Castelli, Ilaria
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Fontana, Marcella
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Coluccio, Valeria
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Leonardi, Giovanna
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Zucchini, Patrizia
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Tripodo, Claudio
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Cuneo, Antonio
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Gattei, Valter
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Del Poeta, Giovanni
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Forconi, Francesco
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Gaidano, Gianluca
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Torelli, Giuseppe
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Marasca, Roberto
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Maffei, Rossana, Martinelli, Silvia, Santachiara, Rita, Rossi, Davide, Guarnotta, Carla, Sozzi, Elisa, Zucchetto, Antonella, Rigolin, Gian Matteo, Fiorcari, Stefania, Castelli, Ilaria, Fontana, Marcella, Coluccio, Valeria, Leonardi, Giovanna, Zucchini, Patrizia, Tripodo, Claudio, Cuneo, Antonio, Gattei, Valter, Del Poeta, Giovanni, Forconi, Francesco, Gaidano, Gianluca, Torelli, Giuseppe and Marasca, Roberto (2010) Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia. Blood, 116 (4), 584-592. (doi:10.1182/blood-2009-11-252494). (PMID:20382847)

Record type: Article

Abstract

The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive of reduced TTFT (P < .001) and overall survival (P = .002). Multivariate analysis confirmed that high Ang2 was an independent prognosticator for TTFT (hazard ratio = 1.739; 95% confidence interval, 1.059-2.857; P = .029). Significant associations were found between high Ang2 and advanced Binet stages (P < .001), high beta(2)-microglobulin (P < .001), unmutated variable region of immunoglobulin heavy chain gene status (P < .001), high CD38 and zeta-chain-associated protein kinase 70 expression (P < .001 and P = .003), and intermediate/high cytogenetic risk (P = .005). Moreover, Ang2 added prognostic power to other conventional prognosticators and helped to refine prognosis among CLL subsets with both high and low vascular endothelial growth factor plasma levels. Ang2 plasma level may be a useful independent prognosticator for CLL.

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More information

e-pub ahead of print date: 9 April 2010
Published date: 29 July 2010
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 341163
URI: http://eprints.soton.ac.uk/id/eprint/341163
ISSN: 0006-4971
PURE UUID: 7db26a03-8158-4ad4-bfc4-fd0e179dd1a3
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831

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Date deposited: 17 Jul 2012 08:44
Last modified: 15 Mar 2024 03:40

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Contributors

Author: Rossana Maffei
Author: Silvia Martinelli
Author: Rita Santachiara
Author: Davide Rossi
Author: Carla Guarnotta
Author: Elisa Sozzi
Author: Antonella Zucchetto
Author: Gian Matteo Rigolin
Author: Stefania Fiorcari
Author: Ilaria Castelli
Author: Marcella Fontana
Author: Valeria Coluccio
Author: Giovanna Leonardi
Author: Patrizia Zucchini
Author: Claudio Tripodo
Author: Antonio Cuneo
Author: Valter Gattei
Author: Giovanni Del Poeta
Author: Gianluca Gaidano
Author: Giuseppe Torelli
Author: Roberto Marasca

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