The University of Southampton
University of Southampton Institutional Repository

Reduced coagulation at high altitude identified by thromboeslastography

Martin, D.S., Pate, J.S., Vercueil, A., Doyle, P.W., Mythen, M.G. and Grocott, Michael P. W. The Caudwell Xtreme Everest Research Group (2012) Reduced coagulation at high altitude identified by thromboeslastography Thrombosis and Haemostasis, 107, (6), pp. 1066-1071. (doi:10.1160/TH12-01-0004). (PMID:22437051).

Record type: Article

Abstract

The impact of hypoxaemia on blood coagulation remains unclear despite use of a variety of measures to address the issue. We report the first use of thromboelastography (TEG) at high altitude to describe the dynamics of clot formation in whole blood samples. Seventeen healthy volunteers ascended to 5,300 m following an identical ascent profile; TEG measurements at 4,250 m and 5,300 m were compared with those from sea level. Peripheral oxygen saturation (SpO2) and haematocrit were also measured. Ascent resulted in a decline in SpO2 from 97.8 (± 1.2) % at sea level to 86.9 (± 3.3) % at 4,250 m and 79.5 (± 5.8) % at 5,300 m (p<0.001); haematocrit rose from 43.7 (± 2.8) % at sea level, to 46.7 (± 3.9) % and 52.6 (± 3.2) % at 4,250 m and 5,300 m, respectively (p<0.01). TEG reaction (R)-time and kinetic (K)-time were both increased at 5,300 m compared to sea level, 8.95 (± 1.37) minutes (min) to 11.69 (± 2.91) min (p=0.016) and 2.40 (± 0.66) min to 4.99 (± 1.67) min (p<0.001), respectively. Additionally the alpha (?)- angle was decreased from 57.7 (± 8.2) to 51.6 (± 6.4) (p<0.001). There was no change in maximum amplitude (MA) on ascent to altitude. These changes are consistent with an overall pattern of slowed coagulation at high altitude.

PDF 341308GROCOTT1.pdf - Version of Record
Restricted to Repository staff only
Download (250kB)

More information

Published date: June 2012
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 341308
URI: http://eprints.soton.ac.uk/id/eprint/341308
ISSN: 0340-6245
PURE UUID: 47a60326-3c33-46d5-840b-8997a3b738cb

Catalogue record

Date deposited: 19 Jul 2012 08:40
Last modified: 18 Jul 2017 05:37

Export record

Altmetrics

Contributors

Author: D.S. Martin
Author: J.S. Pate
Author: A. Vercueil
Author: P.W. Doyle
Author: M.G. Mythen

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×