BRCA1exon 11 alternative splicing, multiple functions and the association with cancer
BRCA1exon 11 alternative splicing, multiple functions and the association with cancer
BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary epithelial cells. The importance of this difference in the pathogenesis of breast cancer has yet to be determined. Developing an understanding of the impact of BRCA1 isoform ratio changes on cell phenotype will be of value in breast cancer and may offer therapeutic options. In the present paper, we describe the splicing isoforms of BRCA1 exon 11, their possible role in cancer biology and the importance of maintaining a balanced ratio
768-772
Tammaro, Claudia
ced23db8-fe5b-45dd-a00c-6b09f4c84999
Raponi, Michela
f465e77f-b9bf-4c32-80d6-43c0787542b9
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Baralle, Diana
faac16e5-7928-4801-9811-8b3a9ea4bb91
1 August 2012
Tammaro, Claudia
ced23db8-fe5b-45dd-a00c-6b09f4c84999
Raponi, Michela
f465e77f-b9bf-4c32-80d6-43c0787542b9
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Baralle, Diana
faac16e5-7928-4801-9811-8b3a9ea4bb91
Tammaro, Claudia, Raponi, Michela, Wilson, David I. and Baralle, Diana
(2012)
BRCA1exon 11 alternative splicing, multiple functions and the association with cancer.
Biochemical Society Transactions, 40 (4), .
(doi:10.1042/BST20120140).
(PMID:22817731)
Abstract
BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary epithelial cells. The importance of this difference in the pathogenesis of breast cancer has yet to be determined. Developing an understanding of the impact of BRCA1 isoform ratio changes on cell phenotype will be of value in breast cancer and may offer therapeutic options. In the present paper, we describe the splicing isoforms of BRCA1 exon 11, their possible role in cancer biology and the importance of maintaining a balanced ratio
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Published date: 1 August 2012
Organisations:
Human Development & Health
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Local EPrints ID: 341501
URI: http://eprints.soton.ac.uk/id/eprint/341501
ISSN: 0300-5127
PURE UUID: 5a0a8ab2-ad94-40c2-93c1-3c4c7433771e
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Date deposited: 27 Jul 2012 09:07
Last modified: 15 Mar 2024 03:30
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Author:
Claudia Tammaro
Author:
Michela Raponi
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