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Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier

Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier
Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier
ransglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis and its reduction is implicated in psoriasis. To understand the importance of TGase 3 in vivo we have generated and analyzed mice lacking this protein. Surprisingly, these animals display no obvious defect in skin development, no overt changes in barrier function or ability to heal wounds. In contrast, hair lacking TGase 3 is thinner, has major alterations in the cuticle cells and hair protein cross-linking is markedly decreased. Apparently, while TGase 3 is of unique functional importance in hair, in the epidermis loss of TGase 3 can be compensated for by other family members
1932-6203
e34252
John, Susan
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Thiebach, Lars
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Frie, Christian
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Mokkapati, Sharada
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Bechtel, Manuela
43daafab-63b9-485a-9560-c576a2dd13ba
Nischt, Roswitha
a21a90aa-1297-42f1-acff-25b2fdb890e5
Rosser-Davies, Sally
cf2e6052-d774-4499-b86c-6de783f0a3eb
Paulsson, Mats
6b6500dc-6e7c-477b-96be-8ebdf82224bf
Smyth, Neil
0eba2a40-3b43-4d40-bb64-621bd7e9d505
John, Susan
c21deb07-f543-48cf-8e33-cf068a55609a
Thiebach, Lars
5aa5816c-b96f-40e9-a694-d6a342fc3f21
Frie, Christian
f6f99d99-b55f-433c-bbde-2ea251688719
Mokkapati, Sharada
2450f3e7-fbb4-4ec3-a856-b74035a2370a
Bechtel, Manuela
43daafab-63b9-485a-9560-c576a2dd13ba
Nischt, Roswitha
a21a90aa-1297-42f1-acff-25b2fdb890e5
Rosser-Davies, Sally
cf2e6052-d774-4499-b86c-6de783f0a3eb
Paulsson, Mats
6b6500dc-6e7c-477b-96be-8ebdf82224bf
Smyth, Neil
0eba2a40-3b43-4d40-bb64-621bd7e9d505

John, Susan, Thiebach, Lars, Frie, Christian, Mokkapati, Sharada, Bechtel, Manuela, Nischt, Roswitha, Rosser-Davies, Sally, Paulsson, Mats and Smyth, Neil (2012) Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier. PLoS ONE, 7 (4), e34252. (doi:10.1371/journal.pone.0034252).

Record type: Article

Abstract

ransglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis and its reduction is implicated in psoriasis. To understand the importance of TGase 3 in vivo we have generated and analyzed mice lacking this protein. Surprisingly, these animals display no obvious defect in skin development, no overt changes in barrier function or ability to heal wounds. In contrast, hair lacking TGase 3 is thinner, has major alterations in the cuticle cells and hair protein cross-linking is markedly decreased. Apparently, while TGase 3 is of unique functional importance in hair, in the epidermis loss of TGase 3 can be compensated for by other family members

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PLoS_ONE:_Epidermal_Transglutaminase_(TGase_3)_Is_Required_for_Proper_Hair_Development,_but_Not_the_Formation_of_the_Epidermal_Barrier.pdf - Version of Record
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Published date: 4 April 2012
Organisations: Biomedicine, Centre for Biological Sciences

Identifiers

Local EPrints ID: 341507
URI: http://eprints.soton.ac.uk/id/eprint/341507
ISSN: 1932-6203
PURE UUID: d1c8df8d-8b8c-4f42-8766-8416063930a4

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Date deposited: 27 Jul 2012 09:13
Last modified: 02 Dec 2019 20:56

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