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The effect of parental allergy on childhood allergic diseases depends on the sex of the child

The effect of parental allergy on childhood allergic diseases depends on the sex of the child
The effect of parental allergy on childhood allergic diseases depends on the sex of the child
BACKGROUND: The parent-of-origin effect is important in understanding the genetic basis of childhood allergic diseases and improving our ability to identify high-risk children.

OBJECTIVE: We sought to investigate the parent-of-origin effect in childhood allergic diseases.

METHODS: The Isle of Wight Birth Cohort (n = 1456) has been examined at 1, 2, 4, 10, and 18 years of age. Information on the prevalence of asthma, eczema, rhinitis, and environmental factors was obtained by using validated questionnaires. Skin prick tests were carried out at ages 4, 10, and 18 years, and total IgE measurement was carried out at 10 and 18 years. Parental history of allergic disease was assessed soon after the birth of the child, when maternal IgE levels were also measured. Prevalence ratios (PRs) and their 95% CIs were estimated, applying log-linear models adjusted for confounding variables.

RESULTS: When stratified for sex of the child, maternal asthma was associated with asthma in girls (PR, 1.91; 95% CI, 1.34-2.72; P = .0003) but not in boys (PR, 1.29; 95% CI, 0.85-1.96; P = .23), whereas paternal asthma was associated with asthma in boys (PR, 1.99; 95% CI, 1.42-2.79; P < .0001) but not in girls (PR, 1.03; 95% CI, 0.59-1.80; P = .92). Maternal eczema increased the risk of eczema in girls (PR, 1.92; 95% CI, 1.37-2.68; P = .0001) only, whereas paternal eczema did the same for boys (PR, 2.07; 95% CI, 1.32-3.25; P = .002). Similar trends were observed when the effect of maternal and paternal allergic disease was assessed for childhood atopy and when maternal total IgE levels were related to total IgE levels in children at ages 10 and 18 years.

CONCLUSIONS: The current study indicates a sex-dependent association of parental allergic conditions with childhood allergies, with maternal allergy increasing the risk in girls and paternal allergy increasing the risk in boys. This has implications for childhood allergy prediction and prevention.
maternal, paternal, sex, cohort, parent of origin, atopy, asthma, eczema, rhinitis, allergy, ige
0091-6749
427-434.e6
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Raza, Abid
bba8b06c-46af-4f7e-acf5-26dba73fc5f3
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, Sharon M.
8286afa1-179a-4392-9603-0dab6da298ea
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Sadeghnejad, Alireza
e2b0fa73-429f-4818-9f24-127f36c57752
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Ewart, Susan L.
48158071-d7b8-46b5-8aef-26ffb37eec3b
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Raza, Abid
bba8b06c-46af-4f7e-acf5-26dba73fc5f3
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, Sharon M.
8286afa1-179a-4392-9603-0dab6da298ea
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Sadeghnejad, Alireza
e2b0fa73-429f-4818-9f24-127f36c57752
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Ewart, Susan L.
48158071-d7b8-46b5-8aef-26ffb37eec3b

Arshad, S. Hasan, Karmaus, Wilfried, Raza, Abid, Kurukulaaratchy, Ramesh J., Matthews, Sharon M., Holloway, John W., Sadeghnejad, Alireza, Zhang, Hongmei, Roberts, Graham and Ewart, Susan L. (2012) The effect of parental allergy on childhood allergic diseases depends on the sex of the child. Journal of Allergy and Clinical Immunology, 130 (2), 427-434.e6. (doi:10.1016/j.jaci.2012.03.042). (PMID:22607991)

Record type: Article

Abstract

BACKGROUND: The parent-of-origin effect is important in understanding the genetic basis of childhood allergic diseases and improving our ability to identify high-risk children.

OBJECTIVE: We sought to investigate the parent-of-origin effect in childhood allergic diseases.

METHODS: The Isle of Wight Birth Cohort (n = 1456) has been examined at 1, 2, 4, 10, and 18 years of age. Information on the prevalence of asthma, eczema, rhinitis, and environmental factors was obtained by using validated questionnaires. Skin prick tests were carried out at ages 4, 10, and 18 years, and total IgE measurement was carried out at 10 and 18 years. Parental history of allergic disease was assessed soon after the birth of the child, when maternal IgE levels were also measured. Prevalence ratios (PRs) and their 95% CIs were estimated, applying log-linear models adjusted for confounding variables.

RESULTS: When stratified for sex of the child, maternal asthma was associated with asthma in girls (PR, 1.91; 95% CI, 1.34-2.72; P = .0003) but not in boys (PR, 1.29; 95% CI, 0.85-1.96; P = .23), whereas paternal asthma was associated with asthma in boys (PR, 1.99; 95% CI, 1.42-2.79; P < .0001) but not in girls (PR, 1.03; 95% CI, 0.59-1.80; P = .92). Maternal eczema increased the risk of eczema in girls (PR, 1.92; 95% CI, 1.37-2.68; P = .0001) only, whereas paternal eczema did the same for boys (PR, 2.07; 95% CI, 1.32-3.25; P = .002). Similar trends were observed when the effect of maternal and paternal allergic disease was assessed for childhood atopy and when maternal total IgE levels were related to total IgE levels in children at ages 10 and 18 years.

CONCLUSIONS: The current study indicates a sex-dependent association of parental allergic conditions with childhood allergies, with maternal allergy increasing the risk in girls and paternal allergy increasing the risk in boys. This has implications for childhood allergy prediction and prevention.

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More information

e-pub ahead of print date: 18 May 2012
Published date: August 2012
Keywords: maternal, paternal, sex, cohort, parent of origin, atopy, asthma, eczema, rhinitis, allergy, ige
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 341582
URI: https://eprints.soton.ac.uk/id/eprint/341582
ISSN: 0091-6749
PURE UUID: 7666d953-dd56-4901-953d-80c17ab6631b
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 30 Jul 2012 10:16
Last modified: 29 Oct 2019 02:01

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Contributors

Author: S. Hasan Arshad
Author: Wilfried Karmaus
Author: Abid Raza
Author: Ramesh J. Kurukulaaratchy
Author: Sharon M. Matthews
Author: Alireza Sadeghnejad
Author: Hongmei Zhang
Author: Graham Roberts
Author: Susan L. Ewart

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