The University of Southampton
University of Southampton Institutional Repository

What does adolescent undiagnosed-wheeze represent? Findings from the Isle of Wight Cohort

Raza, Abid, Kurukulaaratchy, Ramesh J., Grundy, Jane D., Clayton, C. Bernie, Mitchell, Frances A., Roberts, Graham, Ewart, Susan, Sadeghnejad, Alireza and Arshad, S Hasan (2012) What does adolescent undiagnosed-wheeze represent? Findings from the Isle of Wight Cohort European Respiratory Journal, 40, (3), pp. 580-588. (doi:10.1183/09031936.00085111). (PMID:22267759).

Record type: Article


We sought to characterise adolescent wheeze in the absence of asthma, which we termed “undiagnosed-wheeze”.

The Isle of Wight Birth Cohort (N=1456) was reviewed at 1, 2, 4, 10 and 18-years. Using questionnaire responses, “Asthma” was defined as “ever had asthma” plus either “wheezing in the last 12-months” or “taking asthma treatment in the last 12-months”, “Undiagnosed-wheeze” as “wheeze in the last 12-months” but “no” to “ever had asthma” and remaining subjects termed “non-wheezers”.

Undiagnosed-wheeze (prevalence 4.9%) accounted for 22% of wheezing at 18-years. This was largely adolescent-onset with similar symptom frequency and severity to diagnosed asthma. However, undiagnosed-wheezers had significantly higher FEV1/FVC ratio, less bronchodilator reversibility and bronchial hyper-responsiveness, and were less frequently atopic than asthmatics. Undiagnosed-wheezers had earlier smoking onset, higher smoking rates and monthly paracetamol use than non-wheezers. Logistic regression identified paracetamol use (OR 1.11, [95%CI 1.01–1.23]; p=0.03), smoking at 18-years (2.54, [1.19–5.41], p=0.02), rhinitis at 18 (2.82, [1.38–5.73], p=0.004) and asthmatic family history (2.26, [1.10–4.63], p=0.03) as significant independent risk factors for undiagnosed-wheeze.

Undiagnosed-wheeze is relatively common during adolescence, differs from diagnosed asthma and has strong associations to smoking and paracetamol use. Better recognition of undiagnosed-wheeze and assessment of potential relevance to adult health is warranted.

Full text not available from this repository.

More information

e-pub ahead of print date: 20 January 2012
Published date: September 2012
Keywords: asthma, lung function, paracetamol, smoking, undiagnosed wheeze, wheezing phenotype
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 341588
ISSN: 0903-1936
PURE UUID: b17c8649-dc12-4a4f-8b2b-343b4d000d10

Catalogue record

Date deposited: 30 Jul 2012 10:22
Last modified: 18 Jul 2017 05:34

Export record



Author: Abid Raza
Author: Ramesh J. Kurukulaaratchy
Author: Jane D. Grundy
Author: C. Bernie Clayton
Author: Frances A. Mitchell
Author: Graham Roberts
Author: Susan Ewart
Author: Alireza Sadeghnejad
Author: S Hasan Arshad

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.