Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis
Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis
Various genes regulate the intensity of the inflammatory and coagulation response to infection and therefore might determine the severity and outcome of meningococcal disease. We systematically reviewed the published work for case–control studies on the influence of host genetics on severity and outcome in meningococcal disease and identified 27 studies including 7245 patients, with an overall mortality of 10% (range 1–19%). Despite flaws in the methods of the studies there was a clear association of host genetics with mortality and severity in meningococcal disease. Polymorphisms in SERPINE1 (odds ratio [OR] 2·23, 95% CI 1·48–3·35), IL1RN (OR 1·85, 95% CI 1·25–2·76) and IL1B (OR 1·81, 95% CI 1·09–2·97) were associated with mortality in our meta-analyses. In conclusion, gene variation influences severity and mortality in meningococcal disease. Polymorphisms might have potential as prognostic markers or to determine tailor-made adjunctive therapy. Carefully designed, prospective, whole-genome association studies and randomised clinical trials of treatments in specific genetic subgroups are needed
262-274
Brouwer, Matthijs C.
9f6b7e36-b59c-4b09-94be-08a1bae1feb7
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
van de Beek, Diederik
935991f4-e35e-4599-8f21-111f1875ebb6
April 2010
Brouwer, Matthijs C.
9f6b7e36-b59c-4b09-94be-08a1bae1feb7
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
van de Beek, Diederik
935991f4-e35e-4599-8f21-111f1875ebb6
Brouwer, Matthijs C., Read, Robert C. and van de Beek, Diederik
(2010)
Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis.
The Lancet Infectious Diseases, 10 (4), .
(doi:10.1016/S1473-3099(10)70045-1).
(PMID:20334849)
Abstract
Various genes regulate the intensity of the inflammatory and coagulation response to infection and therefore might determine the severity and outcome of meningococcal disease. We systematically reviewed the published work for case–control studies on the influence of host genetics on severity and outcome in meningococcal disease and identified 27 studies including 7245 patients, with an overall mortality of 10% (range 1–19%). Despite flaws in the methods of the studies there was a clear association of host genetics with mortality and severity in meningococcal disease. Polymorphisms in SERPINE1 (odds ratio [OR] 2·23, 95% CI 1·48–3·35), IL1RN (OR 1·85, 95% CI 1·25–2·76) and IL1B (OR 1·81, 95% CI 1·09–2·97) were associated with mortality in our meta-analyses. In conclusion, gene variation influences severity and mortality in meningococcal disease. Polymorphisms might have potential as prognostic markers or to determine tailor-made adjunctive therapy. Carefully designed, prospective, whole-genome association studies and randomised clinical trials of treatments in specific genetic subgroups are needed
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e-pub ahead of print date: 22 March 2010
Published date: April 2010
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 341692
URI: http://eprints.soton.ac.uk/id/eprint/341692
ISSN: 1473-3099
PURE UUID: 4600f3c2-e144-4d37-8307-0853a5bae768
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Date deposited: 06 Aug 2012 10:34
Last modified: 15 Mar 2024 03:42
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Author:
Matthijs C. Brouwer
Author:
Diederik van de Beek
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