The University of Southampton
University of Southampton Institutional Repository

Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis

Brouwer, Matthijs C., Read, Robert C. and van de Beek, Diederik (2010) Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis The Lancet Infectious Diseases, 10, (4), pp. 262-274. (doi:10.1016/S1473-3099(10)70045-1). (PMID:20334849).

Record type: Article

Abstract

Various genes regulate the intensity of the inflammatory and coagulation response to infection and therefore might determine the severity and outcome of meningococcal disease. We systematically reviewed the published work for case–control studies on the influence of host genetics on severity and outcome in meningococcal disease and identified 27 studies including 7245 patients, with an overall mortality of 10% (range 1–19%). Despite flaws in the methods of the studies there was a clear association of host genetics with mortality and severity in meningococcal disease. Polymorphisms in SERPINE1 (odds ratio [OR] 2·23, 95% CI 1·48–3·35), IL1RN (OR 1·85, 95% CI 1·25–2·76) and IL1B (OR 1·81, 95% CI 1·09–2·97) were associated with mortality in our meta-analyses. In conclusion, gene variation influences severity and mortality in meningococcal disease. Polymorphisms might have potential as prognostic markers or to determine tailor-made adjunctive therapy. Carefully designed, prospective, whole-genome association studies and randomised clinical trials of treatments in specific genetic subgroups are needed

Full text not available from this repository.

More information

e-pub ahead of print date: 22 March 2010
Published date: April 2010
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 341692
URI: http://eprints.soton.ac.uk/id/eprint/341692
ISSN: 1473-3099
PURE UUID: 4600f3c2-e144-4d37-8307-0853a5bae768

Catalogue record

Date deposited: 06 Aug 2012 10:34
Last modified: 18 Jul 2017 05:33

Export record

Altmetrics

Contributors

Author: Matthijs C. Brouwer
Author: Robert C. Read
Author: Diederik van de Beek

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×