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Identifying the cellular basis for reimplantation failure in repair of the rotator cuff

Simon, D.W.N., Clarkin, C.E., Das-Gupta, V., Rawlinson, S.C.F., Emery, R.J. and Pitsillides, A.A. (2008) Identifying the cellular basis for reimplantation failure in repair of the rotator cuff Journal of Bone and Joint Surgery, British Volume, 90-B, (5), pp. 680-684. (doi:10.1302/0301-620X.90B5.20013). (PMID:18450641).

Record type: Article


We examined cultured osteoblasts derived from paired samples from the greater tuberosity and acromion from eight patients with large chronic tears of the rotator cuff.

We found that osteoblasts from the tuberosity had no apparent response to mechanical stimulation, whereas those derived from the acromion showed an increase in alkaline phosphatase activity and nitric oxide release which is normally a response of bone cells to mechanical strain. By contrast, we found that cells from both regions were able to respond to dexamethasone, a well-established promoter of osteoblastic differentiation, with the expected increase in alkaline phosphatase activity.

Our findings indicate that the failure of repair of the rotator cuff may be due, at least in part, to a compromised capacity for mechanoadaptation within the greater tuberosity. It remains to be seen whether this apparent decrease in the sensitivity of bone cells to mechanical stimulation is the specific consequence of the reduced load-bearing history of the greater tuberosity in these patients.

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Published date: May 2008
Organisations: Biomedicine


Local EPrints ID: 341967
ISSN: 0301-620X
PURE UUID: ced64ac7-a66a-4922-b2e8-a3385d6b6976

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Date deposited: 09 Aug 2012 10:57
Last modified: 18 Jul 2017 05:31

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Author: D.W.N. Simon
Author: C.E. Clarkin
Author: V. Das-Gupta
Author: S.C.F. Rawlinson
Author: R.J. Emery
Author: A.A. Pitsillides

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