The University of Southampton
University of Southampton Institutional Repository

Effects of Ginkgo biloba on mental functioning in healthy volunteers

Cieza, Alarcos, Maier, Petra and Pöppel, Ernst (2003) Effects of Ginkgo biloba on mental functioning in healthy volunteers Archives of Medical Research, 34, (5), pp. 373-381. (doi:10.1016/j.arcmed.2003.05.001). (PMID:14602503).

Record type: Article


Background: There has been a lack of investigations examining the effects of Ginkgo biloba extract EGb 761® on mental functions and quality of life in healthy subjects with no cognitive impairment. Thus, the objective of the present study was to evaluate the relatively short-term (i.e., 4 weeks) effects of EGb 761® on mental functioning and quality of life in healthy volunteers.

Methods: The trial was conducted as a 4-week, randomized, double-blind, placebo-controlled, parallel-group, monocentric study. Sixty six healthy volunteers aged between 50 and 65 years without age-associated cognitive impairment were randomized, 32 into the placebo and 34 into the EGb 761®-treatment group (240 mg, tid). Safety and compliance were monitored after 1, 2, 3 and 4 weeks.

Primary outcome measures in this study are the subjects' judgment of their own mental health (MH), their general health (GH) and their quality of life (QoL) operationalized on the basis of three different visual analog scales (VAS). Secondary outcome measures are 15 tests and experimental procedures based on a neurobiologically based classification or taxonomy of functions.

Results: Intergroup differences in self-estimated mental health as well as self-estimated quality of life were significant in favor of EGb 761®. No intergroup differences were found in self-estimated general health. Secondary outcomes supporting the notion of superiority of the active drug were found for both motor performance and emotional evaluation. This study did not reveal evidence of unknown drug-induced side effects or intolerance. No serious adverse events were observed during the study.

Conclusions: Both questions treated in this study, efficacy and safety, are important from a medical perspective because many persons take the agent studied in an effort to enhance their mental functioning and general well-being. The findings of this study support the adequacy of intake of EGb 761® to improve the functions indicated previously.

Full text not available from this repository.

More information

Published date: September 2003
Keywords: ginkgo biloba, elderly, cognitive function, randomized clinical trial, neuropsychologic tests, phytotherapy, plant-extract pharmacology, plants, medicinal, central nervous system agents
Organisations: Psychology


Local EPrints ID: 342079
ISSN: 0188-4409
PURE UUID: 3299d15e-c4c2-4d53-8afc-8cb8813a57a7

Catalogue record

Date deposited: 11 Aug 2012 12:16
Last modified: 18 Jul 2017 05:31

Export record



Author: Alarcos Cieza
Author: Petra Maier
Author: Ernst Pöppel

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.