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Identifying the concepts contained in outcome measures of clinical trials on depressive disorders using the International Classification of Functioning, Disability and Health as a reference

Identifying the concepts contained in outcome measures of clinical trials on depressive disorders using the International Classification of Functioning, Disability and Health as a reference
Identifying the concepts contained in outcome measures of clinical trials on depressive disorders using the International Classification of Functioning, Disability and Health as a reference
Objectives: First, to systematically identify the concepts contained in outcome measures of trials on depressive disorders using the International Classification of Functioning, Disability and Health (ICF) as a reference. Secondly, to explore differences in the use of ICF categories across different intervention types. Thirdly, to examine which and how often health status measures have been applied in trials on depressive disorders.

Methods: Randomized controlled trials between 1991 and 2000 were located in MEDLINE and selected according to predefined criteria. The outcome measures were extracted and the concepts contained in the outcome measures were linked to the ICF.

Results: A random sample of 203 (50%) of 406 eligible studies were included. The 5 most used ICF categories (range 88-94%) were sleep functions (b134), emotional functions (b152), energy and drive functions (b130), thought functions (b160) and higher-level cognitive functions (b164), all belonging to the body functions component. The use of ICF categories did not vary across different intervention types. A total of 126 different health status measures were extracted. The Hamilton Rating Scale for Depression was the most used health status measure applied in 80% of the studies.

Conclusion: Concepts about execution of tasks/actions, participation in life situations, and the influence of the environment were under-represented in the outcome assessment of trials on depressive disorders. These observations indicate that most trials were limited in their ability to assess more global individual outcomes.
1650-1977
49-55
Brockow, Thomas
72a8d26e-6a1d-4278-a62f-ad706dccf493
Wohlfahrt, Kathrin
f7596432-9e53-471b-99fc-b90b697c7850
Hillert, Andreas
354418d8-0938-44f8-b65f-f1d48131cbd5
Geyh, Szilvia
277a9f7e-1e41-48ef-ad1a-cb91f559f215
Weigl, Martin
edac7f2c-9b57-4b6f-bb81-1d54f248db06
Franke, Thomas
1de80c16-8284-492b-9e59-15497261948b
Resch, Karl Ludwig
5af71625-6d8d-4037-acb8-54e459a7d656
Cieza, Alarcos
a0df25c5-ee2c-4580-82b3-d0a75591580e
Brockow, Thomas
72a8d26e-6a1d-4278-a62f-ad706dccf493
Wohlfahrt, Kathrin
f7596432-9e53-471b-99fc-b90b697c7850
Hillert, Andreas
354418d8-0938-44f8-b65f-f1d48131cbd5
Geyh, Szilvia
277a9f7e-1e41-48ef-ad1a-cb91f559f215
Weigl, Martin
edac7f2c-9b57-4b6f-bb81-1d54f248db06
Franke, Thomas
1de80c16-8284-492b-9e59-15497261948b
Resch, Karl Ludwig
5af71625-6d8d-4037-acb8-54e459a7d656
Cieza, Alarcos
a0df25c5-ee2c-4580-82b3-d0a75591580e

Brockow, Thomas, Wohlfahrt, Kathrin, Hillert, Andreas, Geyh, Szilvia, Weigl, Martin, Franke, Thomas, Resch, Karl Ludwig and Cieza, Alarcos (2004) Identifying the concepts contained in outcome measures of clinical trials on depressive disorders using the International Classification of Functioning, Disability and Health as a reference. Journal of Rehabilitation Medicine, 36, supplement 44, 49-55. (doi:10.1080/16501960410015380). (PMID:15370748)

Record type: Article

Abstract

Objectives: First, to systematically identify the concepts contained in outcome measures of trials on depressive disorders using the International Classification of Functioning, Disability and Health (ICF) as a reference. Secondly, to explore differences in the use of ICF categories across different intervention types. Thirdly, to examine which and how often health status measures have been applied in trials on depressive disorders.

Methods: Randomized controlled trials between 1991 and 2000 were located in MEDLINE and selected according to predefined criteria. The outcome measures were extracted and the concepts contained in the outcome measures were linked to the ICF.

Results: A random sample of 203 (50%) of 406 eligible studies were included. The 5 most used ICF categories (range 88-94%) were sleep functions (b134), emotional functions (b152), energy and drive functions (b130), thought functions (b160) and higher-level cognitive functions (b164), all belonging to the body functions component. The use of ICF categories did not vary across different intervention types. A total of 126 different health status measures were extracted. The Hamilton Rating Scale for Depression was the most used health status measure applied in 80% of the studies.

Conclusion: Concepts about execution of tasks/actions, participation in life situations, and the influence of the environment were under-represented in the outcome assessment of trials on depressive disorders. These observations indicate that most trials were limited in their ability to assess more global individual outcomes.

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Published date: July 2004
Organisations: Psychology

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Local EPrints ID: 342257
URI: https://eprints.soton.ac.uk/id/eprint/342257
ISSN: 1650-1977
PURE UUID: c89c7986-2115-4eb7-88b6-0c8b227df3a9

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Date deposited: 17 Aug 2012 10:55
Last modified: 18 Jul 2017 05:30

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Contributors

Author: Thomas Brockow
Author: Kathrin Wohlfahrt
Author: Andreas Hillert
Author: Szilvia Geyh
Author: Martin Weigl
Author: Thomas Franke
Author: Karl Ludwig Resch
Author: Alarcos Cieza

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