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Sequence and genome organization of a human small round-structured (Norwalk-like) virus

Lambden, P.R., Caul, E.O., Ashley, C.R. and Clarke, I.N. (1993) Sequence and genome organization of a human small round-structured (Norwalk-like) virus Science, 259, (5094), pp. 516-519. (doi:10.1126/science.8380940). (PMID:8380940).

Record type: Article


Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.

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Published date: 22 January 1993
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 342333
ISSN: 0036-8075
PURE UUID: 31673681-5309-4829-af86-9375a159c76d
ORCID for I.N. Clarke: ORCID iD

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Date deposited: 22 Aug 2012 10:40
Last modified: 18 Jul 2017 05:29

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Author: P.R. Lambden
Author: E.O. Caul
Author: C.R. Ashley
Author: I.N. Clarke ORCID iD

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