Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view neglects the fact that lung matrix can only be degraded by proteases. We propose an original conceptual framework of TB immunopathology that may lead directly to treatments that involve inhibition of matrix metalloproteinase activity to hinder matrix destruction and reduce the morbidity and mortality associated with TB
71-76
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
D'Armiento, Jeanine M.
312ae21c-d0cf-4d15-bc39-530612294480
Friedland, Jon S.
9968669f-afe0-4163-9b35-3b476246fd4a
February 2011
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
D'Armiento, Jeanine M.
312ae21c-d0cf-4d15-bc39-530612294480
Friedland, Jon S.
9968669f-afe0-4163-9b35-3b476246fd4a
Elkington, Paul T., D'Armiento, Jeanine M. and Friedland, Jon S.
(2011)
Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.
Science Translational Medicine, 3 (71), .
(doi:10.1126/scitranslmed.3001847).
(PMID:21346167)
Abstract
The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view neglects the fact that lung matrix can only be degraded by proteases. We propose an original conceptual framework of TB immunopathology that may lead directly to treatments that involve inhibition of matrix metalloproteinase activity to hinder matrix destruction and reduce the morbidity and mortality associated with TB
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TB_Matrix_Elkington.pdf
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Published date: February 2011
Organisations:
Faculty of Medicine
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Local EPrints ID: 342368
URI: http://eprints.soton.ac.uk/id/eprint/342368
ISSN: 1946-6234
PURE UUID: 74ba6be2-22af-455a-9182-e2e68ea2b37c
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Date deposited: 23 Aug 2012 14:03
Last modified: 15 Mar 2024 03:43
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Author:
Jeanine M. D'Armiento
Author:
Jon S. Friedland
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