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Tuberculosis immunopathology: the neglected role of extracellular matrix destruction

Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
Tuberculosis immunopathology: the neglected role of extracellular matrix destruction
The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view neglects the fact that lung matrix can only be degraded by proteases. We propose an original conceptual framework of TB immunopathology that may lead directly to treatments that involve inhibition of matrix metalloproteinase activity to hinder matrix destruction and reduce the morbidity and mortality associated with TB
1946-6234
71-76
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
D'Armiento, Jeanine M.
312ae21c-d0cf-4d15-bc39-530612294480
Friedland, Jon S.
9968669f-afe0-4163-9b35-3b476246fd4a
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
D'Armiento, Jeanine M.
312ae21c-d0cf-4d15-bc39-530612294480
Friedland, Jon S.
9968669f-afe0-4163-9b35-3b476246fd4a

Elkington, Paul T., D'Armiento, Jeanine M. and Friedland, Jon S. (2011) Tuberculosis immunopathology: the neglected role of extracellular matrix destruction. Science Translational Medicine, 3 (71), 71-76. (doi:10.1126/scitranslmed.3001847). (PMID:21346167)

Record type: Article

Abstract

The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view neglects the fact that lung matrix can only be degraded by proteases. We propose an original conceptual framework of TB immunopathology that may lead directly to treatments that involve inhibition of matrix metalloproteinase activity to hinder matrix destruction and reduce the morbidity and mortality associated with TB

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Published date: February 2011
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 342368
URI: http://eprints.soton.ac.uk/id/eprint/342368
ISSN: 1946-6234
PURE UUID: 74ba6be2-22af-455a-9182-e2e68ea2b37c
ORCID for Paul T. Elkington: ORCID iD orcid.org/0000-0003-0390-0613

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Date deposited: 23 Aug 2012 14:03
Last modified: 18 Feb 2021 17:19

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Contributors

Author: Jeanine M. D'Armiento
Author: Jon S. Friedland

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