Watts, Jonathan K. and Damha, Masad J.
2?F-Arabinonucleic acids (2?F-ANA) — history, properties, and new frontiers
Canadian Journal of Chemistry, 86, (7), . (doi:10.1139/V08-049).
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The development of arabinonucleosides and oligoarabinonucleotides is described, focusing especially on 2?-deoxy-2?-fluoroarabinonucleosides (araF-N) and -oligonucleotides (2'F-ANA). In addition to their chemical and enzymatic synthesis, we discuss various properties of 2?F-ANA: hydrolytic stability (to nucleases, acids, and bases), binding affinity to complementary strands, structure and conformation, and optimization of RNase H activity. We also discuss the use of 2?F-ANA in gene-silencing approaches (antisense, siRNA), and in the stabilization of higher-order structures (such as triplexes and quadruplexes) including aptamers. Finally, we examine several other oligonucleotide derivatives based on 2?F-ANA and look ahead to the future of 2?-fluoroarabinonucleosides and -oligonucleotide
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