The University of Southampton
University of Southampton Institutional Repository

2?F-Arabinonucleic acids (2?F-ANA) — history, properties, and new frontiers

Watts, Jonathan K. and Damha, Masad J. (2008) 2?F-Arabinonucleic acids (2?F-ANA) — history, properties, and new frontiers Canadian Journal of Chemistry, 86, (7), pp. 641-656. (doi:10.1139/V08-049).

Record type: Article


The development of arabinonucleosides and oligoarabinonucleotides is described, focusing especially on 2?-deoxy-2?-fluoroarabinonucleosides (araF-N) and -oligonucleotides (2'F-ANA). In addition to their chemical and enzymatic synthesis, we discuss various properties of 2?F-ANA: hydrolytic stability (to nucleases, acids, and bases), binding affinity to complementary strands, structure and conformation, and optimization of RNase H activity. We also discuss the use of 2?F-ANA in gene-silencing approaches (antisense, siRNA), and in the stabilization of higher-order structures (such as triplexes and quadruplexes) including aptamers. Finally, we examine several other oligonucleotide derivatives based on 2?F-ANA and look ahead to the future of 2?-fluoroarabinonucleosides and -oligonucleotide

Full text not available from this repository.

More information

Published date: July 2008
Organisations: Chemistry, Organic Chemistry: SCF


Local EPrints ID: 342433
PURE UUID: b39ddd24-c563-4a53-a740-1fabb36e5eaf

Catalogue record

Date deposited: 29 Aug 2012 11:50
Last modified: 18 Jul 2017 05:28

Export record



Author: Jonathan K. Watts
Author: Masad J. Damha

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.