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Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment

Coussens, A.K., Wilkinson, R.J., Hanifa, Y., Nikolayevskyy, V., Elkington, P.T., Islam, K., Timms, P., Venton, T.R., Bothamley, G.H., Packe, G.E., Darmalingam, M., Davidson, R.N., Milburn, H.J., Baker, L.V., Barker, R.D., Mein, C.A., Bhaw-Rosun, L., Nuamah, R., Young, D.B., Drobniewski, F.A., Griffiths, C.J. and Martineau, A.R. (2012) Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment Proceedings of the National Academy of Sciences, 109, pp. 15449-54. (doi:10.1073/pnas.1200072109).

Record type: Article


Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol concentrations, and thus has a potential role in the prevention and treatment of infection. The immunomodulatory effects of administering vitamin D to humans with an infectious disease have not previously been reported. To characterize these effects, we conducted a detailed longitudinal study of circulating and antigen-stimulated immune responses in ninety-five patients receiving antimicrobial therapy for pulmonary tuberculosis who were randomized to receive adjunctive high-dose vitamin D or placebo in a clinical trial, and who fulfilled criteria for per-protocol analysis. Vitamin D supplementation accelerated sputum smear conversion and enhanced treatment-induced resolution of lymphopaenia, monocytosis, hypercytokinaemia, and hyperchemokinaemia. Administration of vitamin D also suppressed antigen-stimulated proinflammatory cytokine responses, but attenuated the suppressive effect of antimicrobial therapy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-?. We demonstrate a previously unappreciated role for vitamin D supplementation in accelerating resolution of inflammatory responses during tuberculosis treatment. Our findings suggest a potential role for adjunctive vitamin D supplementation in the treatment of pulmonary infections to accelerate resolution of inflammatory responses associated with increased risk of mortality.

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Published date: 4 September 2012
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 342551
ISSN: 0027-8424
PURE UUID: 28a8d26a-ca2d-4bcf-a2ad-34a7892486c1
ORCID for P.T. Elkington: ORCID iD

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Date deposited: 06 Sep 2012 13:25
Last modified: 18 Jul 2017 05:28

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Author: A.K. Coussens
Author: R.J. Wilkinson
Author: Y. Hanifa
Author: V. Nikolayevskyy
Author: P.T. Elkington ORCID iD
Author: K. Islam
Author: P. Timms
Author: T.R. Venton
Author: G.H. Bothamley
Author: G.E. Packe
Author: M. Darmalingam
Author: R.N. Davidson
Author: H.J. Milburn
Author: L.V. Baker
Author: R.D. Barker
Author: C.A. Mein
Author: L. Bhaw-Rosun
Author: R. Nuamah
Author: D.B. Young
Author: F.A. Drobniewski
Author: C.J. Griffiths
Author: A.R. Martineau

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