Viruses as building blocks for materials and devices
Viruses as building blocks for materials and devices
From the viewpoint of a materials scientist, viruses can be regarded as organic nanoparticles. They are composed of a small number of different (bio)polymers: proteins and nucleic acids. Many viruses are enveloped in a lipid membrane and all viruses do not have a metabolism of their own, but rather use the metabolic machinery of a living cell for their replication. Their surface carries specific tools designed to cross the barriers of their host cells. The size and shape of viruses, and the number and nature of the functional groups on their surface, is precisely defined. As such, viruses are commonly used in materials science as scaffolds for covalently linked surface modifications. A particular quality of viruses is that they can be tailored by directed evolution by taking advantage of their inbuilt colocalization of geno- and phenotypes. The powerful techniques developed by life sciences are becoming the basis of engineering approaches towards nanomaterials, opening a wide range of applications far beyond biology and medicine
3184-3193
Fischlechner, Martin
b3930129-0775-4c05-81c7-475934df97ee
Donath, Edwin
a1baee66-cc02-4a15-8c0d-732e844b8a8f
27 April 2007
Fischlechner, Martin
b3930129-0775-4c05-81c7-475934df97ee
Donath, Edwin
a1baee66-cc02-4a15-8c0d-732e844b8a8f
Fischlechner, Martin and Donath, Edwin
(2007)
Viruses as building blocks for materials and devices.
Angewandte Chemie International Edition, 46 (18), .
(doi:10.1002/anie.200603445).
Abstract
From the viewpoint of a materials scientist, viruses can be regarded as organic nanoparticles. They are composed of a small number of different (bio)polymers: proteins and nucleic acids. Many viruses are enveloped in a lipid membrane and all viruses do not have a metabolism of their own, but rather use the metabolic machinery of a living cell for their replication. Their surface carries specific tools designed to cross the barriers of their host cells. The size and shape of viruses, and the number and nature of the functional groups on their surface, is precisely defined. As such, viruses are commonly used in materials science as scaffolds for covalently linked surface modifications. A particular quality of viruses is that they can be tailored by directed evolution by taking advantage of their inbuilt colocalization of geno- and phenotypes. The powerful techniques developed by life sciences are becoming the basis of engineering approaches towards nanomaterials, opening a wide range of applications far beyond biology and medicine
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Accepted/In Press date: 9 March 2007
Published date: 27 April 2007
Organisations:
Organic Chemistry: SCF
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Local EPrints ID: 342560
URI: http://eprints.soton.ac.uk/id/eprint/342560
ISSN: 1433-7851
PURE UUID: 592e5f7e-4745-49f9-ac9b-e0c5631e48ad
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Date deposited: 19 Oct 2012 07:59
Last modified: 14 Mar 2024 11:52
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Author:
Martin Fischlechner
Author:
Edwin Donath
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