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Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring

Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring
Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring
The period around the time of conception is one characterised by considerable cytological and molecular restructuring as ovulation occurs, the oocyte is fertilised and the embryonic developmental programme begins. The intrinsic processes regulating peri-conceptional progression are supplemented by environmental factors, which contribute important metabolic information that influences several aspects of the developmental programme. Indeed, there is growing evidence from different mammalian animal models, reviewed here, that the peri-conceptional environment mediated through maternal nutrition can modify development throughout gestation and affect the physiological and metabolic health of adult offspring. The concept that adult disease risk may owe its origin to the quality of peri-conceptional maternal nutrition is one, which merits further research for mechanistic understanding and devising preventive strategies.

developmental programming, diet, embryo, mouse, nutrition, obesity, oocyte, sheep
0378-4320
193-197
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, M.A.
706e7de5-8cdb-4f2b-b47d-128166bdbea4
Eckert, J.J.
729bfa49-7053-458d-8e84-3e70e4d98e57
Lucas, E.S.
4f46398a-5f53-4e61-875e-40b5013b1d2d
Watkins, A.J.
106e91fc-632c-4a7b-b412-30118a75ce4e
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, M.A.
706e7de5-8cdb-4f2b-b47d-128166bdbea4
Eckert, J.J.
729bfa49-7053-458d-8e84-3e70e4d98e57
Lucas, E.S.
4f46398a-5f53-4e61-875e-40b5013b1d2d
Watkins, A.J.
106e91fc-632c-4a7b-b412-30118a75ce4e

Fleming, T.P., Velazquez, M.A., Eckert, J.J., Lucas, E.S. and Watkins, A.J. (2012) Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. [in special issue: Reproductive Health Management of Sheep and Goats] Animal Reproduction Science, 130 (3-4), 193-197. (doi:10.1016/j.anireprosci.2012.01.015). (PMID:22341375)

Record type: Article

Abstract

The period around the time of conception is one characterised by considerable cytological and molecular restructuring as ovulation occurs, the oocyte is fertilised and the embryonic developmental programme begins. The intrinsic processes regulating peri-conceptional progression are supplemented by environmental factors, which contribute important metabolic information that influences several aspects of the developmental programme. Indeed, there is growing evidence from different mammalian animal models, reviewed here, that the peri-conceptional environment mediated through maternal nutrition can modify development throughout gestation and affect the physiological and metabolic health of adult offspring. The concept that adult disease risk may owe its origin to the quality of peri-conceptional maternal nutrition is one, which merits further research for mechanistic understanding and devising preventive strategies.

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More information

e-pub ahead of print date: 25 January 2012
Published date: February 2012
Keywords: developmental programming, diet, embryo, mouse, nutrition, obesity, oocyte, sheep
Organisations: Biomedicine, Human Development & Health

Identifiers

Local EPrints ID: 343319
URI: http://eprints.soton.ac.uk/id/eprint/343319
ISSN: 0378-4320
PURE UUID: 60b61720-8b18-4c66-bbe7-cf4d56e83405

Catalogue record

Date deposited: 03 Oct 2012 10:34
Last modified: 16 Jul 2019 21:53

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Contributors

Author: T.P. Fleming
Author: M.A. Velazquez
Author: J.J. Eckert
Author: E.S. Lucas
Author: A.J. Watkins

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