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Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials

Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials
Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials
Background. There is no curative treatment for primary Sj¨ogren’s syndrome (PSS). Chinese herbal medicine (CHM) is widely used in the treatment of PSS in China. Objective. To evaluate the effectiveness and safety of CHM for PSS. Methods. PubMed, Cochrane Library, China Knowledge Resource Integrated Database, Chinese Biomedical Database, Wanfang Data, and the Database for Chinese Technical Periodicals were searched for randomized controlled trials (RCTs) of CHMor CHM plus conventional medicine for PSS compared with placebo or conventional medicine. RevMan 5.0.17 was employed to conduct data analyses and assess homogeneity. Statistical models were chosen according to heterogeneity. Results. A total of 52 RCTs were included. The overall
methodological quality of included trials was low. 49 trials reported response rates, of which 32 found significant improvements favoring CHM treatment against controls; 20 trials reported lacrimal function by Schirmer test scores, of which 16 trials reported a significant difference favoring CHM treatment. 21 trials reported salivary function by salivary flow rate, of which 10 reported significant favorable effects of CHM treatment. Other trials found no difference. The reported adverse effects of CHM included nausea, diarrhea, and other minor digestive symptoms, but more frequent adverse effects occurred in conventional medicine groups. Conclusions. Preliminary evidence from RCTs suggests the effect of CHM is promising for relieving symptoms, improving
lacrimal and salivary function in PSS. However, the poor methodological quality of the included trials means that further welldesigned, multicentered, larger trials are needed.
1741-427X
Luo, Hui
8714682c-b7ba-4537-a1ae-10dc979a0960
Liu, Jianping
4699004b-2872-49f2-b2f9-f90a061a29db
Li, Xinxue
956da432-db90-43ce-85c4-4d263d4d3f6e
Flower, Andrew
5256a2c8-6e74-49be-acc8-463ed3c18c6a
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Luo, Hui
8714682c-b7ba-4537-a1ae-10dc979a0960
Liu, Jianping
4699004b-2872-49f2-b2f9-f90a061a29db
Li, Xinxue
956da432-db90-43ce-85c4-4d263d4d3f6e
Flower, Andrew
5256a2c8-6e74-49be-acc8-463ed3c18c6a
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625

Luo, Hui, Liu, Jianping, Li, Xinxue, Flower, Andrew and Lewith, George (2012) Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials. Evidence-Based Complementary and Alternative Medicine, 2012 (640658). (doi:10.1155/2012/640658). (PMID:22969828)

Record type: Article

Abstract

Background. There is no curative treatment for primary Sj¨ogren’s syndrome (PSS). Chinese herbal medicine (CHM) is widely used in the treatment of PSS in China. Objective. To evaluate the effectiveness and safety of CHM for PSS. Methods. PubMed, Cochrane Library, China Knowledge Resource Integrated Database, Chinese Biomedical Database, Wanfang Data, and the Database for Chinese Technical Periodicals were searched for randomized controlled trials (RCTs) of CHMor CHM plus conventional medicine for PSS compared with placebo or conventional medicine. RevMan 5.0.17 was employed to conduct data analyses and assess homogeneity. Statistical models were chosen according to heterogeneity. Results. A total of 52 RCTs were included. The overall
methodological quality of included trials was low. 49 trials reported response rates, of which 32 found significant improvements favoring CHM treatment against controls; 20 trials reported lacrimal function by Schirmer test scores, of which 16 trials reported a significant difference favoring CHM treatment. 21 trials reported salivary function by salivary flow rate, of which 10 reported significant favorable effects of CHM treatment. Other trials found no difference. The reported adverse effects of CHM included nausea, diarrhea, and other minor digestive symptoms, but more frequent adverse effects occurred in conventional medicine groups. Conclusions. Preliminary evidence from RCTs suggests the effect of CHM is promising for relieving symptoms, improving
lacrimal and salivary function in PSS. However, the poor methodological quality of the included trials means that further welldesigned, multicentered, larger trials are needed.

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More information

e-pub ahead of print date: 27 August 2012
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 343411
URI: http://eprints.soton.ac.uk/id/eprint/343411
ISSN: 1741-427X
PURE UUID: 467def32-971d-492a-8161-b9a2f340a6bc

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Date deposited: 04 Oct 2012 15:25
Last modified: 08 Nov 2021 23:12

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Contributors

Author: Hui Luo
Author: Jianping Liu
Author: Xinxue Li
Author: Andrew Flower
Author: George Lewith

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