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Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials

Record type: Article

Background. There is no curative treatment for primary Sj¨ogren’s syndrome (PSS). Chinese herbal medicine (CHM) is widely used in the treatment of PSS in China. Objective. To evaluate the effectiveness and safety of CHM for PSS. Methods. PubMed, Cochrane Library, China Knowledge Resource Integrated Database, Chinese Biomedical Database, Wanfang Data, and the Database for Chinese Technical Periodicals were searched for randomized controlled trials (RCTs) of CHMor CHM plus conventional medicine for PSS compared with placebo or conventional medicine. RevMan 5.0.17 was employed to conduct data analyses and assess homogeneity. Statistical models were chosen according to heterogeneity. Results. A total of 52 RCTs were included. The overall
methodological quality of included trials was low. 49 trials reported response rates, of which 32 found significant improvements favoring CHM treatment against controls; 20 trials reported lacrimal function by Schirmer test scores, of which 16 trials reported a significant difference favoring CHM treatment. 21 trials reported salivary function by salivary flow rate, of which 10 reported significant favorable effects of CHM treatment. Other trials found no difference. The reported adverse effects of CHM included nausea, diarrhea, and other minor digestive symptoms, but more frequent adverse effects occurred in conventional medicine groups. Conclusions. Preliminary evidence from RCTs suggests the effect of CHM is promising for relieving symptoms, improving
lacrimal and salivary function in PSS. However, the poor methodological quality of the included trials means that further welldesigned, multicentered, larger trials are needed.

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Citation

Luo, Hui, Liu, Jianping, Li, Xinxue, Flower, Andrew and Lewith, George (2012) Chinese herbal medicine in treating primary Sjögren's syndrome: a systematic review of randomized trials Evidence-based Complementary and Alternative Medicine, 2012, (640658) (doi:10.1155/2012/640658). (PMID:22969828).

More information

e-pub ahead of print date: 27 August 2012
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 343411
URI: http://eprints.soton.ac.uk/id/eprint/343411
ISSN: 1741-427X
PURE UUID: 467def32-971d-492a-8161-b9a2f340a6bc

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Date deposited: 04 Oct 2012 15:25
Last modified: 18 Jul 2017 05:22

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Contributors

Author: Hui Luo
Author: Jianping Liu
Author: Xinxue Li
Author: Andrew Flower
Author: George Lewith

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