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Consolidation and translation regulation

Record type: Article

mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.

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Citation

Gal-Ben-Ari, Shunit, Kenney, Justin W., Ounalla-Saad, Hadile, Taha, Elham, David, Orit, Levitan, David, Gildish, Iness, Panja, Debabrata, Pai, Balagopal, Wibrand, Karin, Simpson, T. Ian, Proud, Christopher G., Bramham, Clive R., Armstrong, J. Douglas and Rosenblum, Kobi (2012) Consolidation and translation regulation Learning & Memory, 19, (9), pp. 410-422. (doi:10.1101/lm.026849.112). (PMID:22353882).

More information

Published date: 16 August 2012
Organisations: Molecular and Cellular

Identifiers

Local EPrints ID: 343513
URI: http://eprints.soton.ac.uk/id/eprint/343513
ISSN: 1072-0502
PURE UUID: 7b0c4991-c3a3-41d2-b0d7-0ee6743c2b35

Catalogue record

Date deposited: 08 Oct 2012 13:43
Last modified: 18 Jul 2017 05:22

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Contributors

Author: Shunit Gal-Ben-Ari
Author: Justin W. Kenney
Author: Hadile Ounalla-Saad
Author: Elham Taha
Author: Orit David
Author: David Levitan
Author: Iness Gildish
Author: Debabrata Panja
Author: Balagopal Pai
Author: Karin Wibrand
Author: T. Ian Simpson
Author: Christopher G. Proud
Author: Clive R. Bramham
Author: J. Douglas Armstrong
Author: Kobi Rosenblum

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