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Modelling the operational limits of a separation enhancement method for capillary electrophoresis: a designer’s tool

Modelling the operational limits of a separation enhancement method for capillary electrophoresis: a designer’s tool
Modelling the operational limits of a separation enhancement method for capillary electrophoresis: a designer’s tool
We report on a model giving new insight into electrokinetic fluid flow in microfluidic devices, and demonstrate its
use as a tool for designing capillary electrophoresis (CE) systems; particularly lab-on-a-chip applications. The
electroosmotic flow (EOF) is directly related to the zeta-potential which can be dynamically modified by applying a
potential to a zeta-potential modification (ZPM) electrode close to the channel wall [1]. We investigate the effect on
EOF where the zeta-potential is modified along a single channel wall, rather than complete channel coverage. We
consider the effect for a single channel wall because it makes the fabrication process simpler. The EOF affects the
amount of separation attainable in CE systems for a given channel length. We show that with control of the EOF,
separations can be achieved in channels of shorter length. The use of a single electrode introduces peak broadening;
we investigate the effect this has on the separation and the limits it places on the separation enhancement method.
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385
Cranny, A
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Harris, N.R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Wharton, J.A.
965a38fd-d2bc-4a19-a08c-2d4e036aa96b
Wood, R.J.K.
d9523d31-41a8-459a-8831-70e29ffe8a73
Stokes, K.R.
5fb4e7f7-2f7e-4e6e-a045-6d7690626695
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385
Cranny, A
2ebc2ccb-7d3e-4a6a-91ac-9f089741939e
Harris, N.R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Wharton, J.A.
965a38fd-d2bc-4a19-a08c-2d4e036aa96b
Wood, R.J.K.
d9523d31-41a8-459a-8831-70e29ffe8a73
Stokes, K.R.
5fb4e7f7-2f7e-4e6e-a045-6d7690626695

Lewis, Adam P., Cranny, A, Harris, N.R., Green, Nicolas G, Wharton, J.A., Wood, R.J.K. and Stokes, K.R. (2012) Modelling the operational limits of a separation enhancement method for capillary electrophoresis: a designer’s tool. The 26th European Conference on Solid-state Transducers (Eurosensors XXVI), Poland. 09 - 12 Sep 2012.

Record type: Conference or Workshop Item (Poster)

Abstract

We report on a model giving new insight into electrokinetic fluid flow in microfluidic devices, and demonstrate its
use as a tool for designing capillary electrophoresis (CE) systems; particularly lab-on-a-chip applications. The
electroosmotic flow (EOF) is directly related to the zeta-potential which can be dynamically modified by applying a
potential to a zeta-potential modification (ZPM) electrode close to the channel wall [1]. We investigate the effect on
EOF where the zeta-potential is modified along a single channel wall, rather than complete channel coverage. We
consider the effect for a single channel wall because it makes the fabrication process simpler. The EOF affects the
amount of separation attainable in CE systems for a given channel length. We show that with control of the EOF,
separations can be achieved in channels of shorter length. The use of a single electrode introduces peak broadening;
we investigate the effect this has on the separation and the limits it places on the separation enhancement method.

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Published date: 9 September 2012
Venue - Dates: The 26th European Conference on Solid-state Transducers (Eurosensors XXVI), Poland, 2012-09-09 - 2012-09-12
Organisations: Nanoelectronics and Nanotechnology, EEE, nCATS Group

Identifiers

Local EPrints ID: 343745
URI: https://eprints.soton.ac.uk/id/eprint/343745
PURE UUID: 4796eec6-56a9-452e-803e-d38e5881bb8d
ORCID for N.R. Harris: ORCID iD orcid.org/0000-0003-4122-2219
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for J.A. Wharton: ORCID iD orcid.org/0000-0002-3439-017X
ORCID for R.J.K. Wood: ORCID iD orcid.org/0000-0003-0681-9239

Catalogue record

Date deposited: 09 Oct 2012 15:59
Last modified: 20 Jul 2019 01:20

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Contributors

Author: Adam P. Lewis
Author: A Cranny
Author: N.R. Harris ORCID iD
Author: Nicolas G Green ORCID iD
Author: J.A. Wharton ORCID iD
Author: R.J.K. Wood ORCID iD
Author: K.R. Stokes

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