The University of Southampton
University of Southampton Institutional Repository

Determinants of peak oxygen uptake in patients with hypertrophic cardiomyopathy: a single-center study

Magrì, Damiano, Agostoni, Piergiuseppe and Cauti, Fillippo Maria et al. (2012) Determinants of peak oxygen uptake in patients with hypertrophic cardiomyopathy: a single-center study Internal and Emergency Medicine (doi:10.1007/s11739-012-0866-x).

Record type: Article

Abstract

Most patients with hypertrophic cardiomyopathy (HCM) usually complain of a reduced exercise capacity, and several factors have been advocated as possible causes of this clinical feature. The present single-center study was designed to investigate exercise capacity and its main clinical determinants in HCM patients. One hundred ninety seven patients of 223 evaluated underwent a complete clinical assessment, including Doppler echocardiography, cardiopulmonary exercise test (CPET) and, in most cases, cardiac magnetic resonance. The HCM population (male 75 %; age 47 ± 16 years; NYHA class I or II 95 %; left ventricular ejection fraction 61 ± 3 %; resting left ventricular outflow tract gradient ?30 mmHg 22 %; late gadolinium enhancement presence 58 %) showed slightly reduced mean peak oxygen uptake values (pVO2 75 ± 15 %, 23.2 ± 6.7 ml/kg/min) with a significant reduction of the achieved percentage of peak heart rate reserve (%pHRR 65 ± 20 %). Adopting a pVO2 <80 % cut-off value, 59 % of HCM patients showed a reduced exercise capacity. Age, male gender, left atrial size, chronotropic and systolic blood pressure response, ventilatory efficiency, late gadolinium enhancement presence and ?-blocker therapy were independently associated with pVO2 (R 2-adjusted index 0.738). A %pHRR cut-off value of 74 % appeared to most accurately predict an impaired exercise capacity (area under curve 0.90). A great prevalence of reduced exercise capacity is present in NYHA class I–II HCM patients. Notwithstanding its multifactorial genesis, few parameters might be adopted in identifying this feature. In this context, %pHRR value might represent a reliable and easy-to-obtain tool for the clinical evaluation of HCM patients.

Full text not available from this repository.

More information

e-pub ahead of print date: 7 October 2012
Keywords: hypertrophyc cardiomyopathy, cardiopulmonary exercise test, chronotropic incompetence
Organisations: Statistics, Statistical Sciences Research Institute

Identifiers

Local EPrints ID: 343942
URI: http://eprints.soton.ac.uk/id/eprint/343942
ISSN: 1828-0447
PURE UUID: 561a1d0f-b203-4f64-ade0-c1c80b0f2ebc

Catalogue record

Date deposited: 15 Oct 2012 09:12
Last modified: 18 Jul 2017 05:20

Export record

Altmetrics

Contributors

Author: Damiano Magrì
Author: Piergiuseppe Agostoni
Author: Fillippo Maria Cauti
Author: Beatrice Musumeci
Author: Gabriele Egidy Assenza
Author: Carlo Nicola De Cecco
Author: Giuseppe Muscogiuri
Author: Antonello Maruotti
Author: Agnese Ricotta
Author: Erika Pagannone
Author: Laura Marino
Author: Daria Santini
Author: Giulia Proietti
Author: Andrea Serdoz
Author: Francesco Paneni
Author: Massimo Volpe
Author: Camillo Autore

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×