Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction
Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction
The synthesis of spiro compounds via a Michael-Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities.
6953-6955
Companyo, X.
822dd954-1f9b-441e-b35e-135b27836f2d
Zea, A.
f047746c-de4d-495d-93d3-e65b6ee4f4f6
Alba, A.N.R.
0957d959-8cc5-4579-872a-e7195d6cd7a3
Mazzanti, A.
a2afd267-e05f-4974-951b-fa23ada066ea
Moyano, A.
b732b7d6-3125-4c9f-b035-fe95363562d6
Rios Torres, R.
609bedf2-e886-4d62-a676-a32b6f8c1441
2010
Companyo, X.
822dd954-1f9b-441e-b35e-135b27836f2d
Zea, A.
f047746c-de4d-495d-93d3-e65b6ee4f4f6
Alba, A.N.R.
0957d959-8cc5-4579-872a-e7195d6cd7a3
Mazzanti, A.
a2afd267-e05f-4974-951b-fa23ada066ea
Moyano, A.
b732b7d6-3125-4c9f-b035-fe95363562d6
Rios Torres, R.
609bedf2-e886-4d62-a676-a32b6f8c1441
Companyo, X., Zea, A., Alba, A.N.R., Mazzanti, A., Moyano, A. and Rios Torres, R.
(2010)
Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction.
Chemical Communications, 46 (37), .
(doi:10.1039/C0CC01522A).
Abstract
The synthesis of spiro compounds via a Michael-Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities.
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e-pub ahead of print date: 23 August 2010
Published date: 2010
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow
Identifiers
Local EPrints ID: 344088
URI: http://eprints.soton.ac.uk/id/eprint/344088
ISSN: 1359-7345
PURE UUID: 82235a69-4373-440b-b63f-a4f0728b07c8
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Date deposited: 07 Jul 2016 14:14
Last modified: 14 Mar 2024 12:09
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Contributors
Author:
X. Companyo
Author:
A. Zea
Author:
A.N.R. Alba
Author:
A. Mazzanti
Author:
A. Moyano
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