A meta-analytic study of event rate effects on go/no-go performance in attention-deficit/hyperactivity disorder

Metin, Baris, Roeyers, Herbert, Wiersema, Jan R., van der Meere, Jaap and Sonuga-Barke, Edmund (2012) A meta-analytic study of event rate effects on go/no-go performance in attention-deficit/hyperactivity disorder Biological Psychiatry (doi:10.1016/j.biopsych.2012.08.023).


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Background: According to the state regulation deficit model, event rate (ER) is an important determinant of performance of children with attention-deficit/hyperactivity disorder (ADHD). Fast ER is predicted to create overactivation and produce errors of commission, whereas slow ER is thought to create underactivation marked by slow and variable reaction times (RT) and errors of omission.

Methods: To test these predictions, we conducted a systematic search of the literature to identify all reports of comparisons of ADHD and control individuals’ performance on Go/No-Go tasks published between 2000 and 2011. In one analysis, we included all trials with at least two event rates and calculated the difference between ER conditions. In a second analysis, we used metaregression to test for the moderating role of ER on ADHD versus control differences seen across Go/No-Go studies.

Results: There was a significant and disproportionate slowing of reaction time in ADHD relative to controls on trials with slow event rates in both meta-analyses. For commission errors, the effect sizes were larger on trials with fast event rates. No ER effects were seen for RT variability. There were also general effects of ADHD on performance for all variables that persisted after effects of ER were taken into account.

Conclusions: The results provide support for the state regulation deficit model of ADHD by showing the differential effects of fast and slow ER. The lack of an effect of ER on RT variability suggests that this behavioral characteristic may not be a marker of cognitive energetic effects in ADHD.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.biopsych.2012.08.023
ISSNs: 0006-3223 (print)
Keywords: adhd, event rate, go/no-go, meta-analysis, state regulation, task performance
Organisations: Clinical Neuroscience
ePrint ID: 344193
Date :
Date Event
2012Accepted/In Press
October 2012e-pub ahead of print
Date Deposited: 15 Oct 2012 12:40
Last Modified: 17 Apr 2017 16:31
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/344193

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