Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years
Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years
Variation in exposure to polyunsaturated fatty acids (PUFAs) might influence the development of atopy, asthma, and wheeze. This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy. For 865 term-born children, we measured phosphatidylcholine fatty acid composition in maternal plasma collected at 34 weeks' gestation. Wheezing was classified using questionnaires at 6, 12, 24, and 36 months and 6 years. At age of 6 years, the children underwent skin prick testing, fractional exhaled nitric oxide (FENO) measurement, and spirometry. Maternal n-6 fatty acids and the ratio of n-3 to n-6 fatty acids were not associated with childhood wheeze. However, higher maternal eicosapentaenoic acid, docosahexaenoic acid, and total n-3 fatty acids were associated with reduced risk of non-atopic persistent/late wheeze (RR 0.57, 0.67 and 0.69, resp. P = 0.01, 0.015, and 0.021, resp.). Maternal arachidonic acid was positively associated with FENO (P = 0.024). A higher ratio of linoleic acid to its unsaturated metabolic products was associated with reduced risk of skin sensitisation (RR 0.82, P = 0.013). These associations provide some support for the hypothesis that variation in exposure to n-6 and n-3 fatty acids during pregnancy influences the risk of childhood wheeze and atopy.
474613
Pike, Katharine C.
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Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Roberts, Graham C.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lucas, Jane S.A.
5cb3546c-87b2-4e59-af48-402076e25313
2012
Pike, Katharine C.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Roberts, Graham C.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lucas, Jane S.A.
5cb3546c-87b2-4e59-af48-402076e25313
Pike, Katharine C., Calder, Philip C., Inskip, Hazel M., Robinson, Sian M., Roberts, Graham C., Cooper, Cyrus, Godfrey, Keith M. and Lucas, Jane S.A.
(2012)
Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years.
Clinical and Developmental Immunology, 2012, .
(doi:10.1155/2012/474613).
(PMID:23049600)
Abstract
Variation in exposure to polyunsaturated fatty acids (PUFAs) might influence the development of atopy, asthma, and wheeze. This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy. For 865 term-born children, we measured phosphatidylcholine fatty acid composition in maternal plasma collected at 34 weeks' gestation. Wheezing was classified using questionnaires at 6, 12, 24, and 36 months and 6 years. At age of 6 years, the children underwent skin prick testing, fractional exhaled nitric oxide (FENO) measurement, and spirometry. Maternal n-6 fatty acids and the ratio of n-3 to n-6 fatty acids were not associated with childhood wheeze. However, higher maternal eicosapentaenoic acid, docosahexaenoic acid, and total n-3 fatty acids were associated with reduced risk of non-atopic persistent/late wheeze (RR 0.57, 0.67 and 0.69, resp. P = 0.01, 0.015, and 0.021, resp.). Maternal arachidonic acid was positively associated with FENO (P = 0.024). A higher ratio of linoleic acid to its unsaturated metabolic products was associated with reduced risk of skin sensitisation (RR 0.82, P = 0.013). These associations provide some support for the hypothesis that variation in exposure to n-6 and n-3 fatty acids during pregnancy influences the risk of childhood wheeze and atopy.
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Published date: 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 344354
URI: http://eprints.soton.ac.uk/id/eprint/344354
ISSN: 1740-2522
PURE UUID: 5dfb11ef-7a7a-43fd-b619-6b999316ceb3
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Date deposited: 19 Oct 2012 15:51
Last modified: 18 Mar 2024 03:01
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Author:
Katharine C. Pike
Author:
Sian M. Robinson
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