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Phylodynamics and human-mediated dispersal of a zoonotic virus

Phylodynamics and human-mediated dispersal of a zoonotic virus
Phylodynamics and human-mediated dispersal of a zoonotic virus
Understanding the role of humans in the dispersal of predominantly animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens.
algeria/epidemiology, animals, computer simulation demography, dogs, evolution, molecular gene flow, genetics, physiology, geography, humans, morocco, epidemiology, phylogeny, rabies virus, physiologytunisia, zoonoses, transmission, virology
1553-7366
e1001166-[10pp]
Talbi, C.
65ecfe18-b33d-4436-a1ca-5473eca20126
Lemey, P.
d89cf95d-442a-4d96-876d-f26e455a2816
Suchard, M.A.
7927425a-5f75-4ddd-ba84-3c9eb06bc714
Abdelatif, E.
503ae38f-163e-4d9c-ad22-2443a4ee365e
Elharrak, M.
d9498fa6-d5d5-4142-9a0d-ba097202fc2c
Nourlil, J.
fafed1b5-7686-4d55-9f4b-85659ee93065
Faouzi, A.
c9474309-af53-4758-850d-9a032b1d337d
Echevarria, J.E.
0ccca7ae-8d03-4fbb-8b8f-c78b7b621934
Vazquez Moron, S.
cf3d115a-0269-465f-af48-b10c78494e9f
Rambaut, A.
eb1cb910-0eb8-4652-a4be-6a9ffa5d4fbe
Campiz, N.
84136521-d222-4e7b-bc37-cce3302a41ff
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Holmes, E.C.
3679de5a-adee-49d6-9605-62c5016c8c26
Bourhy, H.
98b8686a-91f3-43b3-abb6-67543378c007
Talbi, C.
65ecfe18-b33d-4436-a1ca-5473eca20126
Lemey, P.
d89cf95d-442a-4d96-876d-f26e455a2816
Suchard, M.A.
7927425a-5f75-4ddd-ba84-3c9eb06bc714
Abdelatif, E.
503ae38f-163e-4d9c-ad22-2443a4ee365e
Elharrak, M.
d9498fa6-d5d5-4142-9a0d-ba097202fc2c
Nourlil, J.
fafed1b5-7686-4d55-9f4b-85659ee93065
Faouzi, A.
c9474309-af53-4758-850d-9a032b1d337d
Echevarria, J.E.
0ccca7ae-8d03-4fbb-8b8f-c78b7b621934
Vazquez Moron, S.
cf3d115a-0269-465f-af48-b10c78494e9f
Rambaut, A.
eb1cb910-0eb8-4652-a4be-6a9ffa5d4fbe
Campiz, N.
84136521-d222-4e7b-bc37-cce3302a41ff
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Holmes, E.C.
3679de5a-adee-49d6-9605-62c5016c8c26
Bourhy, H.
98b8686a-91f3-43b3-abb6-67543378c007

Talbi, C., Lemey, P., Suchard, M.A., Abdelatif, E., Elharrak, M., Nourlil, J., Faouzi, A., Echevarria, J.E., Vazquez Moron, S., Rambaut, A., Campiz, N., Tatem, A.J., Holmes, E.C. and Bourhy, H. (2010) Phylodynamics and human-mediated dispersal of a zoonotic virus. PLoS Pathogens, 6 (10), e1001166-[10pp]. (doi:10.1371/journal.ppat.1001166).

Record type: Article

Abstract

Understanding the role of humans in the dispersal of predominantly animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens.

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Published date: 28 October 2010
Keywords: algeria/epidemiology, animals, computer simulation demography, dogs, evolution, molecular gene flow, genetics, physiology, geography, humans, morocco, epidemiology, phylogeny, rabies virus, physiologytunisia, zoonoses, transmission, virology
Organisations: Geography & Environment, PHEW – P (Population Health)

Identifiers

Local EPrints ID: 344451
URI: https://eprints.soton.ac.uk/id/eprint/344451
ISSN: 1553-7366
PURE UUID: d3713348-f908-4539-8d21-d99c52025755
ORCID for A.J. Tatem: ORCID iD orcid.org/0000-0002-7270-941X

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Date deposited: 05 Nov 2012 10:02
Last modified: 03 Dec 2019 01:38

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Contributors

Author: C. Talbi
Author: P. Lemey
Author: M.A. Suchard
Author: E. Abdelatif
Author: M. Elharrak
Author: J. Nourlil
Author: A. Faouzi
Author: J.E. Echevarria
Author: S. Vazquez Moron
Author: A. Rambaut
Author: N. Campiz
Author: A.J. Tatem ORCID iD
Author: E.C. Holmes
Author: H. Bourhy

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