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Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy

Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy
Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy
HIV-1 CRF02_AG accounts for >50% of infected individuals in Cameroon. CRF02_AG prevalence has been increasing both in Africa and Europe, particularly in Italy because of migrations from the sub-Saharan region. This study investigated the molecular epidemiology of CRF02_AG in Cameroon by employing Bayesian phylodynamics and analyzed the relationship between HIV-1 CRF02_AG isolates circulating in Italy and those prevalent in Africa to understand the link between the two epidemics. Among 291 Cameroonian reverse transcriptase sequences analyzed, about 70% clustered within three distinct clades, two of which shared a most recent common ancestor, all related to sequences from Western Africa. The major Cameroonian clades emerged during the mid-1970s and slowly spread during the next 30 years. Little or no geographic structure was detected within these clades. One of the major driving forces of the epidemic was likely the high accessibility between locations in Southern Cameroon contributing to the mobility of the population. The remaining Cameroonian sequences and the new strains isolated from Italian patients were interspersed mainly within West and Central African sequences in the tree, indicating a continuous exchange of CRF02_AG viral strains between Cameroon and other African countries, as well as multiple independent introductions in the Italian population. The evaluation of the spread of CRF02_AG may provide significant insight about the future dynamics of the Italian and European epidemic.
bayes theorem, cameroon, epidemiology, epidemics, genetics, populationHIV Infections/*epidemiologyHIV Reverse Transcriptase/geneticsHIV-1/*classification/*genetics/isolation & purificationHumansItaly/epidemiology*Molecular EpidemiologyPhylogenySequence Analysis, DNA
0889-2229
1173-1182
Veras, N.M.
863b9b49-6894-440b-b4a5-7003d3490fe4
Santoro, M.M.
e4ec5471-932c-4a0f-b8eb-73dc77581922
Gray, R.R.
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Tatem, A.J.
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Lo Presti, A.
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Olearo, F.
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Cappelli, G.
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Colizzi, V.
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Takou, D.
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Torimiro, J.
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Russo, G.
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Callegaro, A.
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Salpini, R.
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D'Arrigo, R.
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Perno, C.F.
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Goodenow, M.M.
e251ecc5-374f-4d37-9f3b-9c3a5136eaa1
Ciccozzi, M.
e10fa97e-c253-4736-89f2-fc45e282fccd
Salemi, M.
c7822d3e-11d0-4184-835a-68f3b7945afc
Veras, N.M.
863b9b49-6894-440b-b4a5-7003d3490fe4
Santoro, M.M.
e4ec5471-932c-4a0f-b8eb-73dc77581922
Gray, R.R.
0865cf96-c9d9-4a13-b6ab-330e5b0b0185
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Lo Presti, A.
d4aa760e-9f9d-4a24-bc70-e2bef6653be2
Olearo, F.
7d7fa4c5-b42d-4803-89a0-f62558595239
Cappelli, G.
d29b3547-fe84-4c43-87b9-dbb45ed6310c
Colizzi, V.
5dec121e-052e-4ba3-914c-0259446ac87f
Takou, D.
2582263c-c8f5-4c1a-85c3-c69e253f440b
Torimiro, J.
a56b1cef-55eb-4a2a-bb66-772a7012418f
Russo, G.
9a6ee167-63e8-49ce-9bcb-5acde287f7b8
Callegaro, A.
ec6ab724-adb7-40ac-afd6-787ea7ca5362
Salpini, R.
f85fed2b-78b6-405d-a0ae-7ed5162c7080
D'Arrigo, R.
dac1dd08-3e52-4cff-af25-2b0468640f32
Perno, C.F.
42f7b7d8-d1bd-4812-a678-5594843184b8
Goodenow, M.M.
e251ecc5-374f-4d37-9f3b-9c3a5136eaa1
Ciccozzi, M.
e10fa97e-c253-4736-89f2-fc45e282fccd
Salemi, M.
c7822d3e-11d0-4184-835a-68f3b7945afc

Veras, N.M., Santoro, M.M., Gray, R.R., Tatem, A.J., Lo Presti, A., Olearo, F., Cappelli, G., Colizzi, V., Takou, D., Torimiro, J., Russo, G., Callegaro, A., Salpini, R., D'Arrigo, R., Perno, C.F., Goodenow, M.M., Ciccozzi, M. and Salemi, M. (2011) Molecular epidemiology of HIV type 1 CRF02_AG in Cameroon and African patients living in Italy. AIDS Research and Human Retroviruses, 27 (11), 1173-1182. (PMID:21453131)

Record type: Article

Abstract

HIV-1 CRF02_AG accounts for >50% of infected individuals in Cameroon. CRF02_AG prevalence has been increasing both in Africa and Europe, particularly in Italy because of migrations from the sub-Saharan region. This study investigated the molecular epidemiology of CRF02_AG in Cameroon by employing Bayesian phylodynamics and analyzed the relationship between HIV-1 CRF02_AG isolates circulating in Italy and those prevalent in Africa to understand the link between the two epidemics. Among 291 Cameroonian reverse transcriptase sequences analyzed, about 70% clustered within three distinct clades, two of which shared a most recent common ancestor, all related to sequences from Western Africa. The major Cameroonian clades emerged during the mid-1970s and slowly spread during the next 30 years. Little or no geographic structure was detected within these clades. One of the major driving forces of the epidemic was likely the high accessibility between locations in Southern Cameroon contributing to the mobility of the population. The remaining Cameroonian sequences and the new strains isolated from Italian patients were interspersed mainly within West and Central African sequences in the tree, indicating a continuous exchange of CRF02_AG viral strains between Cameroon and other African countries, as well as multiple independent introductions in the Italian population. The evaluation of the spread of CRF02_AG may provide significant insight about the future dynamics of the Italian and European epidemic.

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More information

e-pub ahead of print date: May 2011
Published date: 3 November 2011
Keywords: bayes theorem, cameroon, epidemiology, epidemics, genetics, populationHIV Infections/*epidemiologyHIV Reverse Transcriptase/geneticsHIV-1/*classification/*genetics/isolation & purificationHumansItaly/epidemiology*Molecular EpidemiologyPhylogenySequence Analysis, DNA
Organisations: Geography & Environment, PHEW – P (Population Health)

Identifiers

Local EPrints ID: 344485
URI: https://eprints.soton.ac.uk/id/eprint/344485
ISSN: 0889-2229
PURE UUID: 5158ba79-37f8-4bc9-9e66-91f2582ff2df
ORCID for A.J. Tatem: ORCID iD orcid.org/0000-0002-7270-941X

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Date deposited: 29 Oct 2012 11:46
Last modified: 06 Jun 2018 12:28

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Contributors

Author: N.M. Veras
Author: M.M. Santoro
Author: R.R. Gray
Author: A.J. Tatem ORCID iD
Author: A. Lo Presti
Author: F. Olearo
Author: G. Cappelli
Author: V. Colizzi
Author: D. Takou
Author: J. Torimiro
Author: G. Russo
Author: A. Callegaro
Author: R. Salpini
Author: R. D'Arrigo
Author: C.F. Perno
Author: M.M. Goodenow
Author: M. Ciccozzi
Author: M. Salemi

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