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Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA

Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA
Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA
Bone responds to changes in its mechanical environment by removing unloaded tissue and adding new bone in highly loaded areas. Here we show that numerical models that include detailed subject specific muscle and joint forces rather than simplified or more generic loads were able to accurately predict the extent of bone adaptation following hip replacement. The unprecedented in vivo verification of the predictive power of the bone adaptation model provides the essential basis for using such approaches to better match patients to existing implants and develop new devices in order to preserve bone better and ensure longer lasting implant fixation.
Bone responds to changes in its mechanical environment by removing unloaded tissue and adding new bone in highly loaded areas. Here we show that numerical models that include detailed subject specific muscle and joint forces rather than simplified or more generic loads were able to accurately predict the extent of bone adaptation following hip replacement. The unprecedented in vivo verification of the predictive power of the bone adaptation model provides the essential basis for using such approaches to better match patients to existing implants and develop new devices in order to preserve bone better and ensure longer lasting implant fixation.
1932-6203
e36231
Szwedowski, T.D.
79a8f0a8-f31f-4a87-86fc-93838262f11b
Taylor, W.R.
4f1cd2b0-4963-4b10-bbde-da586c069e77
Heller, M.
3da19d2a-f34d-4ff1-8a34-9b5a7e695829
Perka, C.
075d2c0e-b277-4a76-8b14-548bce0bb133
Müller, M.
d806c137-1e7e-48c9-93a9-fea684d8f67e
Duda, G.N.
32d09622-34ad-49dd-8314-3f61c99a764e
Szwedowski, T.D.
79a8f0a8-f31f-4a87-86fc-93838262f11b
Taylor, W.R.
4f1cd2b0-4963-4b10-bbde-da586c069e77
Heller, M.
3da19d2a-f34d-4ff1-8a34-9b5a7e695829
Perka, C.
075d2c0e-b277-4a76-8b14-548bce0bb133
Müller, M.
d806c137-1e7e-48c9-93a9-fea684d8f67e
Duda, G.N.
32d09622-34ad-49dd-8314-3f61c99a764e

Szwedowski, T.D., Taylor, W.R., Heller, M., Perka, C., Müller, M. and Duda, G.N. (2012) Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA. PLoS ONE, 7 (5), e36231. (doi:10.1371/journal.pone.0036231).

Record type: Article

Abstract

Bone responds to changes in its mechanical environment by removing unloaded tissue and adding new bone in highly loaded areas. Here we show that numerical models that include detailed subject specific muscle and joint forces rather than simplified or more generic loads were able to accurately predict the extent of bone adaptation following hip replacement. The unprecedented in vivo verification of the predictive power of the bone adaptation model provides the essential basis for using such approaches to better match patients to existing implants and develop new devices in order to preserve bone better and ensure longer lasting implant fixation.

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Published date: 2 May 2012
Keywords: Bone responds to changes in its mechanical environment by removing unloaded tissue and adding new bone in highly loaded areas. Here we show that numerical models that include detailed subject specific muscle and joint forces rather than simplified or more generic loads were able to accurately predict the extent of bone adaptation following hip replacement. The unprecedented in vivo verification of the predictive power of the bone adaptation model provides the essential basis for using such approaches to better match patients to existing implants and develop new devices in order to preserve bone better and ensure longer lasting implant fixation.
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 345227
URI: https://eprints.soton.ac.uk/id/eprint/345227
ISSN: 1932-6203
PURE UUID: 7d63e6b3-8907-4349-b0df-5e413f4f58e5
ORCID for M. Heller: ORCID iD orcid.org/0000-0002-7879-1135

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Date deposited: 14 Nov 2012 11:32
Last modified: 20 Jul 2019 00:41

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