Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors
Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors
Our findings suggest that neuregulin-ErbB4 signaling is involved in synaptic plasticity and memory impairments in AS model mice, suggesting that ErbB inhibitors have therapeutic potential for the treatment of AS
182-190
Kaphzan, Hanoch
3e4d2300-b5d7-4b33-b3ac-2727dec47cea
Hernandez, Pepe
35a62735-c20b-4ce5-a778-c9d3ca543d28
Jung, Joo In
cfda075b-8886-44ad-8ef6-46d3f75232f4
Cowansage, Kiriana K.
9cdbe28c-86c6-4a0a-86a2-3628f5a201a1
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Chao, Moses V.
823c00e2-9f32-4a7b-a2c4-76e7c1fbf83d
Abel, Ted
b2e82fcd-117d-45f3-8009-91adb0e9eac9
Klann, Eric
15afa55b-aaa0-4575-9a15-0844fe49f6fa
1 August 2012
Kaphzan, Hanoch
3e4d2300-b5d7-4b33-b3ac-2727dec47cea
Hernandez, Pepe
35a62735-c20b-4ce5-a778-c9d3ca543d28
Jung, Joo In
cfda075b-8886-44ad-8ef6-46d3f75232f4
Cowansage, Kiriana K.
9cdbe28c-86c6-4a0a-86a2-3628f5a201a1
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Chao, Moses V.
823c00e2-9f32-4a7b-a2c4-76e7c1fbf83d
Abel, Ted
b2e82fcd-117d-45f3-8009-91adb0e9eac9
Klann, Eric
15afa55b-aaa0-4575-9a15-0844fe49f6fa
Kaphzan, Hanoch, Hernandez, Pepe, Jung, Joo In, Cowansage, Kiriana K., Deinhardt, Katrin, Chao, Moses V., Abel, Ted and Klann, Eric
(2012)
Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors.
Biological Psychiatry, 72 (3), .
(doi:10.1016/j.biopsych.2012.01.021).
(PMID:22381732)
Abstract
Our findings suggest that neuregulin-ErbB4 signaling is involved in synaptic plasticity and memory impairments in AS model mice, suggesting that ErbB inhibitors have therapeutic potential for the treatment of AS
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Published date: 1 August 2012
Organisations:
Faculty of Natural and Environmental Sciences, Centre for Biological Sciences
Identifiers
Local EPrints ID: 345234
URI: http://eprints.soton.ac.uk/id/eprint/345234
ISSN: 0006-3223
PURE UUID: cfebec27-12e9-4123-8f4c-2cb520b01914
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Date deposited: 14 Nov 2012 11:35
Last modified: 15 Mar 2024 03:45
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Contributors
Author:
Hanoch Kaphzan
Author:
Pepe Hernandez
Author:
Joo In Jung
Author:
Kiriana K. Cowansage
Author:
Moses V. Chao
Author:
Ted Abel
Author:
Eric Klann
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