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The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study

The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study
The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study
Objective. To establish the natural history of radiographic knee osteoarthritis (OA) over 14 years in a community-based cohort.
Methods. We examined women from the Chingford Women’s Study, a community-based cohort followed up for more than 14 years. We selected women for whom bilateral radiographs of the knees (with the legs in full extension) were obtained at approximately 5-year intervals. Radiographs were scored for OA in a blinded manner, using Kellgren/Lawrence (K/L) grades. Descriptive statistics and odds ratios (ORs) were used to compare the incidence, worsening, and progression of radiographic knee OA.
Results. A complete radiography series was available for 561 of the original 1,003 subjects enrolled in the study. The median age of these subjects at baseline was 53 years (interquartile range 48–58 years). At baseline, 13.7% of the subjects had radiographic knee OA (K/L grade >2) in at least one knee, and the prevalence increased to 47.8% by year 15. The annual cumulative incidence of radiographic knee OA was 2.3% between baseline and year 15. The annual rates of disease progression and worsening between baseline and year 15 were 2.8% and 3.0%, respectively. Subjects with a K/L grade of 1 at baseline were more likely to experience worsening by year 15 compared with subjects with a baseline grade of 0 (OR 4.5, 95% confidence interval 2.7–7.4).
Conclusion. This is the longest natural history study of radiographic knee OA to date. The results showed relatively low rates for the incidence and progression of radiographic knee OA; more than half of all subjects had no radiographic evidence of knee OA over a 15-year period of time. Subjects with a baseline K/L grade of 1 were more likely than subjects with other baseline K/L grades to experience worsening of knee OA.
0004-3591
2243-2251
Leyland, K. M.
291dd25c-247a-42bd-a51c-55c070d5213e
Hart, D. J.
735e2b00-41b0-46dc-bc28-52b458017c39
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Judge, A.
c6a83964-1d7c-4aa8-b2bf-9c264d1e487d
Kiran, A.
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Soni, A.
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Goulston, L. M.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Spector, T. D.
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Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f
Leyland, K. M.
291dd25c-247a-42bd-a51c-55c070d5213e
Hart, D. J.
735e2b00-41b0-46dc-bc28-52b458017c39
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Judge, A.
c6a83964-1d7c-4aa8-b2bf-9c264d1e487d
Kiran, A.
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Soni, A.
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Goulston, L. M.
281705c9-2335-4173-9387-8526856d75ef
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Spector, T. D.
29debf10-949d-4094-8f5f-9a8614511ccb
Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f

Leyland, K. M., Hart, D. J., Javaid, M.K., Judge, A., Kiran, A., Soni, A., Goulston, L. M., Cooper, C., Spector, T. D. and Arden, N. K. (2012) The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study. Arthritis & Rheumatism, 64 (7), 2243-2251. (doi:10.1002/art.34415). (PMID:22422507)

Record type: Article

Abstract

Objective. To establish the natural history of radiographic knee osteoarthritis (OA) over 14 years in a community-based cohort.
Methods. We examined women from the Chingford Women’s Study, a community-based cohort followed up for more than 14 years. We selected women for whom bilateral radiographs of the knees (with the legs in full extension) were obtained at approximately 5-year intervals. Radiographs were scored for OA in a blinded manner, using Kellgren/Lawrence (K/L) grades. Descriptive statistics and odds ratios (ORs) were used to compare the incidence, worsening, and progression of radiographic knee OA.
Results. A complete radiography series was available for 561 of the original 1,003 subjects enrolled in the study. The median age of these subjects at baseline was 53 years (interquartile range 48–58 years). At baseline, 13.7% of the subjects had radiographic knee OA (K/L grade >2) in at least one knee, and the prevalence increased to 47.8% by year 15. The annual cumulative incidence of radiographic knee OA was 2.3% between baseline and year 15. The annual rates of disease progression and worsening between baseline and year 15 were 2.8% and 3.0%, respectively. Subjects with a K/L grade of 1 at baseline were more likely to experience worsening by year 15 compared with subjects with a baseline grade of 0 (OR 4.5, 95% confidence interval 2.7–7.4).
Conclusion. This is the longest natural history study of radiographic knee OA to date. The results showed relatively low rates for the incidence and progression of radiographic knee OA; more than half of all subjects had no radiographic evidence of knee OA over a 15-year period of time. Subjects with a baseline K/L grade of 1 were more likely than subjects with other baseline K/L grades to experience worsening of knee OA.

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e-pub ahead of print date: 26 June 2012
Published date: July 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 345271
URI: http://eprints.soton.ac.uk/id/eprint/345271
ISSN: 0004-3591
PURE UUID: 47b75953-e769-41b8-b1f0-b205b0fd40bc
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 15 Nov 2012 12:42
Last modified: 10 Dec 2019 01:53

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Contributors

Author: K. M. Leyland
Author: D. J. Hart
Author: M.K. Javaid
Author: A. Judge
Author: A. Kiran
Author: A. Soni
Author: L. M. Goulston
Author: C. Cooper ORCID iD
Author: T. D. Spector
Author: N. K. Arden

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