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Hyperpolarized singlet NMR on a small animal imaging system

Hyperpolarized singlet NMR on a small animal imaging system
Hyperpolarized singlet NMR on a small animal imaging system
Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.
0740-3194
1262-1265
Laustsen, Christoffer
bc7e127b-8cad-4593-b6f7-8233aa72ebab
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047
Laustsen, Christoffer
bc7e127b-8cad-4593-b6f7-8233aa72ebab
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047

Laustsen, Christoffer, Pileio, Giuseppe, Tayler, Michael C.D., Brown, Lynda J., Brown, Richard C.D., Levitt, Malcolm H. and Ardenkjaer-Larsen, Jan H. (2012) Hyperpolarized singlet NMR on a small animal imaging system. Magnetic Resonance in Medicine, 68 (4), 1262-1265. (doi:10.1002/mrm.24430). (PMID:22851334)

Record type: Article

Abstract

Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.

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Published date: July 2012
Organisations: Chemistry

Identifiers

Local EPrints ID: 345405
URI: http://eprints.soton.ac.uk/id/eprint/345405
ISSN: 0740-3194
PURE UUID: 69d11544-516c-436a-acef-3203266ae114
ORCID for Giuseppe Pileio: ORCID iD orcid.org/0000-0001-9223-3896
ORCID for Lynda J. Brown: ORCID iD orcid.org/0000-0002-5678-0814
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180

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Date deposited: 20 Nov 2012 15:27
Last modified: 18 Feb 2021 17:05

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