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Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood

Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood
Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood
Context: Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition.

Objective: We investigated the associations between maternal plasma n-3 and n-6 PUFA status at 34 wk gestation and offspring body composition.

Design and Setting: A prospective United Kingdom population-based mother-offspring cohort, the Southampton Women’s Survey (SWS), was studied.

Participants: A total of 12,583 nonpregnant women were recruited into the SWS, among whom 1987 delivered a baby before December 31, 2003; 293 mother-child pairs had complete measurements of maternal plasma PUFA concentrations in late pregnancy and offspring body composition at both ages 4 and 6 yr.

Main Outcomes Measured: We measured offspring body composition by dual-energy x-ray absorptiometry, yielding fat mass, lean mass, percentage fat mass, and percentage lean mass. Results are presented as -coefficients for standardized variables, therefore reflecting the SD change of the outcome for every 1 SD of the predictor.

Results: After adjustment for maternal factors and child factors including height and duration of breast-feeding, maternal plasma n-6 PUFA concentration positively predicted offspring fat mass at 4 yr (? = 0.14 SD/SD; P = 0.01) and 6 yr (? = 0.11 SD/SD; P = 0.04), but there was no association with offspring lean mass at either age (? = 0.005 SD/SD, P = 0.89; and ? = 0.008 SD/SD, P = 0.81, respectively). Maternal plasma n-3 PUFA concentration was not associated with offspring fat mass at 4yr (? = 0.057 SD/SD; P=0.34) or 6 yr (? = 0.069 SD/SD; P = 0.21). Maternal plasma n-3 PUFA status was positively associated with offspring lean mass on univariate analysis (4 yr, ? = 0.11, P = 0.06; 6 yr,
? = 0.14; P = 0.02); however, this was confounded by a positive association with offspring height.

Conclusions: This observational study suggests that maternal n-6 PUFA status during pregnancy
might influence offspring adiposity in childhood.
0021-972X
299-307
Moon, R. J.
954fb3ed-9934-4649-886d-f65944985a6b
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Robinson, S. M.
ba591c98-4380-456a-be8a-c452f992b69b
Ntani, G.
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Davies, J. H.
9f18fcad-f488-4c72-ac23-c154995443a9
Inskip, H. M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K. M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dennison, E. M.
ee647287-edb4-4392-8361-e59fd505b1d1
Calder, P. C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Moon, R. J.
954fb3ed-9934-4649-886d-f65944985a6b
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Robinson, S. M.
ba591c98-4380-456a-be8a-c452f992b69b
Ntani, G.
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Davies, J. H.
9f18fcad-f488-4c72-ac23-c154995443a9
Inskip, H. M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K. M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dennison, E. M.
ee647287-edb4-4392-8361-e59fd505b1d1
Calder, P. C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Moon, R. J., Harvey, N. C., Robinson, S. M., Ntani, G., Davies, J. H., Inskip, H. M., Godfrey, K. M., Dennison, E. M., Calder, P. C. and Cooper, C. (2013) Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood. Journal of Clinical Endocrinology & Metabolism, 98 (1), 299-307. (doi:10.1210/jc.2012-2482). (PMID:23162098)

Record type: Article

Abstract

Context: Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition.

Objective: We investigated the associations between maternal plasma n-3 and n-6 PUFA status at 34 wk gestation and offspring body composition.

Design and Setting: A prospective United Kingdom population-based mother-offspring cohort, the Southampton Women’s Survey (SWS), was studied.

Participants: A total of 12,583 nonpregnant women were recruited into the SWS, among whom 1987 delivered a baby before December 31, 2003; 293 mother-child pairs had complete measurements of maternal plasma PUFA concentrations in late pregnancy and offspring body composition at both ages 4 and 6 yr.

Main Outcomes Measured: We measured offspring body composition by dual-energy x-ray absorptiometry, yielding fat mass, lean mass, percentage fat mass, and percentage lean mass. Results are presented as -coefficients for standardized variables, therefore reflecting the SD change of the outcome for every 1 SD of the predictor.

Results: After adjustment for maternal factors and child factors including height and duration of breast-feeding, maternal plasma n-6 PUFA concentration positively predicted offspring fat mass at 4 yr (? = 0.14 SD/SD; P = 0.01) and 6 yr (? = 0.11 SD/SD; P = 0.04), but there was no association with offspring lean mass at either age (? = 0.005 SD/SD, P = 0.89; and ? = 0.008 SD/SD, P = 0.81, respectively). Maternal plasma n-3 PUFA concentration was not associated with offspring fat mass at 4yr (? = 0.057 SD/SD; P=0.34) or 6 yr (? = 0.069 SD/SD; P = 0.21). Maternal plasma n-3 PUFA status was positively associated with offspring lean mass on univariate analysis (4 yr, ? = 0.11, P = 0.06; 6 yr,
? = 0.14; P = 0.02); however, this was confounded by a positive association with offspring height.

Conclusions: This observational study suggests that maternal n-6 PUFA status during pregnancy
might influence offspring adiposity in childhood.

Full text not available from this repository.

More information

e-pub ahead of print date: 16 November 2012
Published date: January 2013
Organisations: Biomedical Research Facility (BRF), Human Development & Health

Identifiers

Local EPrints ID: 345484
URI: https://eprints.soton.ac.uk/id/eprint/345484
ISSN: 0021-972X
PURE UUID: 6b2f90df-6c6b-45b7-b848-48144faee4c6
ORCID for N. C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for S. M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for H. M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K. M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for E. M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 22 Nov 2012 11:02
Last modified: 20 Jul 2019 01:27

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Contributors

Author: R. J. Moon
Author: N. C. Harvey ORCID iD
Author: S. M. Robinson ORCID iD
Author: G. Ntani
Author: J. H. Davies
Author: H. M. Inskip ORCID iD
Author: K. M. Godfrey ORCID iD
Author: E. M. Dennison ORCID iD
Author: P. C. Calder
Author: C. Cooper ORCID iD

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