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A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

Sigurdsson, Einar M., Wadghiri, Youssef Z., Mosconi, Lisa, Blind, Jeffrey A., Knudsen, Elin, Asuni, Ayodeji, Scholtzova, Henrieta, Tsui, Wai H., Li, Yongsheng, Sadowski, Martin, Turnbull, Daniel H., de Leon, Mony J. and Wisniewski, Thomas (2008) A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice Neurobiology of Aging, 29, (6), pp. 836-847. (doi:10.1016/j.neurobiolaging.2006.12.018). (PMID:17291630).

Record type: Article

Abstract

Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6A?1–30, which is homologous to A?, and allows plaque detection in vivo. ?MRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTPA-K6A?1–30 in mannitol solution, to transiently open the blood–brain barrier. A gradient echo T2*-weighted sequence was used to provide 100 ?m isotropic resolution with imaging times of 115 min. The scans were examined with voxel-based analysis (VBA) using statistical parametric mapping, for un-biased quantitative comparison of ligand-injected mice and controls. The results indicate that: (1) Gd-DTPA-K6A?1–30 is an effective, non-toxic, ligand for plaque detection when combined with VBA (p ? 0.01–0.001), comparing pre and post-ligand injection scans. (2) Large plaques can be detected without the use of a contrast agent and this detection co-localizes with iron deposition. (3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models.

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More information

e-pub ahead of print date: 8 February 2007
Published date: 2008
Keywords: alzheimer's disease, magnetic resonance imaging, voxel-based analysis, transgenic mice, imaging, amyloid, iron
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 345517
URI: http://eprints.soton.ac.uk/id/eprint/345517
PURE UUID: 72988780-3a50-4dad-bdf5-bce6fb0385e6

Catalogue record

Date deposited: 26 Nov 2012 13:53
Last modified: 18 Jul 2017 05:09

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Contributors

Author: Einar M. Sigurdsson
Author: Youssef Z. Wadghiri
Author: Lisa Mosconi
Author: Jeffrey A. Blind
Author: Elin Knudsen
Author: Ayodeji Asuni
Author: Henrieta Scholtzova
Author: Wai H. Tsui
Author: Yongsheng Li
Author: Martin Sadowski
Author: Daniel H. Turnbull
Author: Mony J. de Leon
Author: Thomas Wisniewski

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