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Modelling tauopathies in Drosophila: insights from the fruit fly.

Modelling tauopathies in Drosophila: insights from the fruit fly.
Modelling tauopathies in Drosophila: insights from the fruit fly.
Drosophila melanogaster is an experimentally tractable model organism that has been used successfully to model aspects of many human neurodegenerative diseases. Drosophila models of tauopathy have provided valuable insights into tau-mediated mechanisms of neuronal dysfunction and death. Here we review the findings from Drosophila models of tauopathy reported over the past ten years and discuss how they have furthered our understanding of the pathogenesis of tauopathies. We also discuss the multitude of technical advantages that Drosophila offers, which make it highly attractive as a model for such studies.
1-16
Cowan, Catherine M.
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Sealey, Megan A.
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Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Targett, Marie-Therese
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Marcellus, Kristen
3e77cd81-f5b7-4718-ba81-71923ad104bd
Allan, Douglas
cfb135cc-e5ae-4fd2-bd9f-14f35ff2992c
Mudher, Amritpal
ce0ccb35-ac49-4b6c-92b4-8dd5e78ac119
Cowan, Catherine M.
9dd8dfb6-bfa9-4388-b386-8e98e188b22a
Sealey, Megan A.
f4f4e7b5-b160-434c-b5e7-a6468283bfdd
Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Targett, Marie-Therese
82d831fd-7677-4dee-9367-ff693f6e3fbd
Marcellus, Kristen
3e77cd81-f5b7-4718-ba81-71923ad104bd
Allan, Douglas
cfb135cc-e5ae-4fd2-bd9f-14f35ff2992c
Mudher, Amritpal
ce0ccb35-ac49-4b6c-92b4-8dd5e78ac119

Cowan, Catherine M., Sealey, Megan A., Quraishe, Shmma, Targett, Marie-Therese, Marcellus, Kristen, Allan, Douglas and Mudher, Amritpal (2011) Modelling tauopathies in Drosophila: insights from the fruit fly. International Journal of Alzheimer's Disease, 2011 (598157), 1-16. (doi:10.4061/2011/598157). (PMID:22254145)

Record type: Article

Abstract

Drosophila melanogaster is an experimentally tractable model organism that has been used successfully to model aspects of many human neurodegenerative diseases. Drosophila models of tauopathy have provided valuable insights into tau-mediated mechanisms of neuronal dysfunction and death. Here we review the findings from Drosophila models of tauopathy reported over the past ten years and discuss how they have furthered our understanding of the pathogenesis of tauopathies. We also discuss the multitude of technical advantages that Drosophila offers, which make it highly attractive as a model for such studies.

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More information

Accepted/In Press date: 2 November 2011
Published date: 2011
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 345542
URI: http://eprints.soton.ac.uk/id/eprint/345542
PURE UUID: 503ebd15-1559-4ef6-8cba-ac2e024124bc

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Date deposited: 14 Mar 2016 12:10
Last modified: 08 Jan 2022 14:58

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Contributors

Author: Catherine M. Cowan
Author: Megan A. Sealey
Author: Shmma Quraishe
Author: Marie-Therese Targett
Author: Kristen Marcellus
Author: Douglas Allan
Author: Amritpal Mudher

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