Relation between AT1R Gene Polymorphism and Long-Term Outcome in Patients with Heart Failure

Amir, Offer, Amir, Ruthie E., Paz, Hagar, Attias, Eric, Sagiv, Michael and Lewis, Basil S. (2009) Relation between AT1R Gene Polymorphism and Long-Term Outcome in Patients with Heart Failure. Cardiology, 112 (2), 151-157. (doi:10.1159/000143390).

Abstract

Objectives: To study differences in the clinical efficacy of various brands of ?-blocker in secondary prevention after a myocardial infarction (MI). Methods: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a ?-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different ?-blockers. Results: The risks for death and recurrent MI were similar in patients using different ?-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of ?-blockers did not show effects on the risk of death or recurrent MI. Conclusion: Except for sotalol, the different types of ?-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately.

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