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ACE ID genotype affects blood creatine kinase response to eccentric exercise

Yamin, Chen, Amir, Offer, Sagiv, Moran, Attias, Eric, Meckel, Yoav, Eynon, Nir, Sagiv, Michael and Amir, Ruthie E. (2007) ACE ID genotype affects blood creatine kinase response to eccentric exercise Journal of Applied Physiology, 103, (6), pp. 2057-2061. (doi:10.1152/japplphysiol.00867.2007). (PMID:17885020).

Record type: Article


Unaccustomed exercise may cause muscle breakdown with marked increase in serum creatine kinase (CK) activity. The skeletal muscle renin-angiotensin system (RAS) plays an important role in exercise metabolism and tissue injury. A functional insertion (I)/deletion (D) polymorphism in the angiotensin I-converting enzyme (ACE) gene (rs4646994) has been associated with ACE activity. We hypothesized that ACE ID genotype may contribute to the wide variability in individuals' CK response to a given exercise. Young individuals performed maximal eccentric contractions of the elbow flexor muscles. Pre- and postexercise CK activity was determined. ACE genotype was significantly associated with postexercise CK increase and peak CK activity. Individuals harboring one or more of the I allele had a greater increase and higher peak CK values than individuals with the DD genotype. This response was dose-dependent (mean ± SE U/L: II, 8,882 ± 2,362; ID, 4,454 ± 1,105; DD, 2,937 ± 753, ANOVA, P = 0.02; P = 0.009 for linear trend). Multivariate stepwise regression analysis, which included age, sex, body mass index, and genotype subtypes, revealed that ACE genotype was the most powerful independent determinant of peak CK activity (adjusted odds ratio 1.3, 95% confidence interval 1.03–1.64, P = 0.02). In conclusion, we indicate a positive association of the ACE ID genotype with CK response to strenuous exercise. We suggest that the II genotype imposes increased risk for developing muscle damage, whereas the DD genotype may have protective effects. These findings support the role of local RAS in the regulation of exertional muscle injury.

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e-pub ahead of print date: 20 September 2007
Published date: December 2007
Keywords: genetics, ace, insertion/deletion, renin-angiotensin system, eccentric exercise
Organisations: Geology & Geophysics


Local EPrints ID: 345598
ISSN: 8750-7587
PURE UUID: a10f2aa9-3855-4bc5-9a0b-d454fecf8d87

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Date deposited: 26 Nov 2012 14:52
Last modified: 18 Jul 2017 05:09

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Author: Chen Yamin
Author: Offer Amir
Author: Moran Sagiv
Author: Eric Attias
Author: Yoav Meckel
Author: Nir Eynon
Author: Michael Sagiv
Author: Ruthie E. Amir

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