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Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review

Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review
Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review
Aim: To evaluate the effectiveness of cardiac markers to quantify anthracycline-induced cardiotoxicity in children with cancer.

Methods: Systematic review using a priori methods.

Results: Seven studies, all with methodological limitations, were identified. One RCT suggests that cardiac troponin can be used to assess the effectiveness of the cardio-protective agent dexrazoxane. Cohort studies suggest that atrial natriuretic peptide and brain (B-type) natriuretic peptide are elevated in some subgroups of patients compared with healthy children; NT-pro-BNP levels are significantly elevated in children with cardiac dysfunction compared with those without; serum lipid peroxide is higher in children who have received doxorubicin compared with children not receiving doxorubicin; there are no differences in carnitine levels between children treated with doxorubicin and a healthy control group.

Conclusions: The limited evidence makes conclusions difficult. Research is needed to fill this important evidence gap and link short-term changes in cardiac markers to longer-term cardiac damage.
anthracyclines, children, cardiac markers, adverse effects, systematic review
0959-8049
1959-1966
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Picot, J.
324d6f20-a105-49fd-9fb0-88791be84ada
Baxter, L.
eeafbfe7-ae7e-421f-a6b6-c6d9df80b6ef
Levitt, G.
e368043e-6492-4b02-9359-e00ec5f0eae8
Sullivan, I.
5ced8efe-2404-4970-93a2-359268870aed
Clegg, A.
838091f5-39df-4dbe-a369-675b26f2301b
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Picot, J.
324d6f20-a105-49fd-9fb0-88791be84ada
Baxter, L.
eeafbfe7-ae7e-421f-a6b6-c6d9df80b6ef
Levitt, G.
e368043e-6492-4b02-9359-e00ec5f0eae8
Sullivan, I.
5ced8efe-2404-4970-93a2-359268870aed
Clegg, A.
838091f5-39df-4dbe-a369-675b26f2301b

Bryant, J., Picot, J., Baxter, L., Levitt, G., Sullivan, I. and Clegg, A. (2007) Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review. European Journal of Cancer, 43 (13), 1959-1966. (doi:10.1016/j.ejca.2007.06.012). (PMID:17689066)

Record type: Article

Abstract

Aim: To evaluate the effectiveness of cardiac markers to quantify anthracycline-induced cardiotoxicity in children with cancer.

Methods: Systematic review using a priori methods.

Results: Seven studies, all with methodological limitations, were identified. One RCT suggests that cardiac troponin can be used to assess the effectiveness of the cardio-protective agent dexrazoxane. Cohort studies suggest that atrial natriuretic peptide and brain (B-type) natriuretic peptide are elevated in some subgroups of patients compared with healthy children; NT-pro-BNP levels are significantly elevated in children with cardiac dysfunction compared with those without; serum lipid peroxide is higher in children who have received doxorubicin compared with children not receiving doxorubicin; there are no differences in carnitine levels between children treated with doxorubicin and a healthy control group.

Conclusions: The limited evidence makes conclusions difficult. Research is needed to fill this important evidence gap and link short-term changes in cardiac markers to longer-term cardiac damage.

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More information

e-pub ahead of print date: 3 August 2007
Published date: September 2007
Keywords: anthracyclines, children, cardiac markers, adverse effects, systematic review
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 345696
URI: http://eprints.soton.ac.uk/id/eprint/345696
ISSN: 0959-8049
PURE UUID: 764c5006-0f7d-43ce-9f74-02774bb6d215
ORCID for J. Picot: ORCID iD orcid.org/0000-0001-5987-996X

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Date deposited: 29 Nov 2012 12:33
Last modified: 31 Jul 2019 00:43

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Contributors

Author: J. Bryant
Author: J. Picot ORCID iD
Author: L. Baxter
Author: G. Levitt
Author: I. Sullivan
Author: A. Clegg

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