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Time-dependent 3D simulations of the hemodynamics in a stented coronary artery

Time-dependent 3D simulations of the hemodynamics in a stented coronary artery
Time-dependent 3D simulations of the hemodynamics in a stented coronary artery
Stenting is becoming the major interventional cardiology procedure worldwide. However restenosis remains a major limitation to the effectiveness of stents. Alterations to the local hemodynamics in the stented segment of the artery could be a potential factor in the development of in-stent restenosis. The characterization of wall shear stress and of blood flow patterns in a stented artery is therefore necessary for a good understanding of the role of hemodynamics in the development of in-stent restenosis. We have used a time-dependent 3D numerical model of a stented coronary artery to study the characteristics of the blood flow and the shear stress distribution. Our results show that the presence of the stent produces significant secondary flow that is limited to an annulus in the near wall region. Low shear stress zones were localized in the vicinity of the struts while the tips of the struts exhibited high values of shear stress. These results support the hypothesis that local hemodynamics may affect the development of in-stent restenosis and could influence the choice of stent geometries for future stent designs.
1748-6041
S28-S37
Faik, I.
f0b1f992-e20c-44ef-8aa6-505e2a700b39
Mongrain, R.
dee6fc5e-d32e-4ef3-be8c-16eacaa5d4ff
Leask, R.
7f7b5ea0-b2a9-4195-8585-23cff0582faa
Rodes-Cabau, J.
25ef2d05-3c03-49e2-a239-bf8ff5e7a3c0
Larose, E.
af356224-29be-46c0-ab7b-6c06ae10c1c5
Bertrand, O.
fc03e510-abe4-4fe7-b552-2ab0434b98c0
Faik, I.
f0b1f992-e20c-44ef-8aa6-505e2a700b39
Mongrain, R.
dee6fc5e-d32e-4ef3-be8c-16eacaa5d4ff
Leask, R.
7f7b5ea0-b2a9-4195-8585-23cff0582faa
Rodes-Cabau, J.
25ef2d05-3c03-49e2-a239-bf8ff5e7a3c0
Larose, E.
af356224-29be-46c0-ab7b-6c06ae10c1c5
Bertrand, O.
fc03e510-abe4-4fe7-b552-2ab0434b98c0

Faik, I., Mongrain, R., Leask, R., Rodes-Cabau, J., Larose, E. and Bertrand, O. (2007) Time-dependent 3D simulations of the hemodynamics in a stented coronary artery. Biomedical Materials, 2, S28-S37. (doi:10.1088/1748-6041/2/1/S05). (PMID:18458417)

Record type: Article

Abstract

Stenting is becoming the major interventional cardiology procedure worldwide. However restenosis remains a major limitation to the effectiveness of stents. Alterations to the local hemodynamics in the stented segment of the artery could be a potential factor in the development of in-stent restenosis. The characterization of wall shear stress and of blood flow patterns in a stented artery is therefore necessary for a good understanding of the role of hemodynamics in the development of in-stent restenosis. We have used a time-dependent 3D numerical model of a stented coronary artery to study the characteristics of the blood flow and the shear stress distribution. Our results show that the presence of the stent produces significant secondary flow that is limited to an annulus in the near wall region. Low shear stress zones were localized in the vicinity of the struts while the tips of the struts exhibited high values of shear stress. These results support the hypothesis that local hemodynamics may affect the development of in-stent restenosis and could influence the choice of stent geometries for future stent designs.

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More information

Published date: 2007
Organisations: Centre for Innovation & Enterprise

Identifiers

Local EPrints ID: 345739
URI: http://eprints.soton.ac.uk/id/eprint/345739
ISSN: 1748-6041
PURE UUID: d4f2c46e-2983-4e50-b497-3223ca3765ad

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Date deposited: 26 Feb 2013 12:54
Last modified: 14 Mar 2024 12:28

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Contributors

Author: I. Faik
Author: R. Mongrain
Author: R. Leask
Author: J. Rodes-Cabau
Author: E. Larose
Author: O. Bertrand

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