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From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects.

From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects.
From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects.
Tissue engineering offers enormous potential for bone regeneration. Despite extensive in vitro and in vivo work, few strategies translate into clinical practice. This paper describes the combination of skeletal stem cells (SSCs) and impaction bone grafting (IBG) for the treatment of patients with bone defects associated with avascular necrosis of the femoral head. SSCs and milled allograft were impacted into necrotic bone in the femoral heads of four patients. Three patients remained asymptomatic at 22-44 month follow-up, but one patient has required total hip replacement (both hips). This has allowed retrieval of the femoral heads, which were analysed structurally and functionally by ?CT, histology and mechanical testing. A central channel of impacted bone was found in the femoral heads, which displayed a mature trabecular micro-architecture. The impacted bone was denser than the surrounding trabecular bone, as strong in compression and with histological micro-architecture comparable to that of trabecular bone. Analysis of the retrieved femoral head samples has demonstrated that this tissue-engineering strategy regenerates bone that is both structurally and functionally analogous to normal trabecular bone. SSCs, together with IBG, have proved an effective treatment for avascular necrosis of the femoral head and offer significant potential for the broader spectrum of bone defects. Copyright © 2012 John Wiley & Sons, Ltd.
1932-6254
Aarvold, A.
cdb23726-6d5e-444a-979a-71ca7af83e3f
Smith, J. O.
5f218718-2cce-488d-9868-f807db4a603e
Tayton, E.R.
2da0fb3a-c242-4f0e-9f70-d7a098b300bd
Jones, A.M.H.
ed691057-0714-4466-a207-79ed730c173c
Dawson, J.I.
fb6e70f3-eec4-484e-9259-8d9d1b0cb169
Lanham, S.
366f5da6-cf09-4a87-9ecd-0b08a902f7ec
Briscoe, A.
bce18fc7-3031-4acc-b570-da949accccd4
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Aarvold, A.
cdb23726-6d5e-444a-979a-71ca7af83e3f
Smith, J. O.
5f218718-2cce-488d-9868-f807db4a603e
Tayton, E.R.
2da0fb3a-c242-4f0e-9f70-d7a098b300bd
Jones, A.M.H.
ed691057-0714-4466-a207-79ed730c173c
Dawson, J.I.
fb6e70f3-eec4-484e-9259-8d9d1b0cb169
Lanham, S.
366f5da6-cf09-4a87-9ecd-0b08a902f7ec
Briscoe, A.
bce18fc7-3031-4acc-b570-da949accccd4
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Aarvold, A., Smith, J. O., Tayton, E.R., Jones, A.M.H., Dawson, J.I., Lanham, S., Briscoe, A., Dunlop, D.G. and Oreffo, R.O.C. (2012) From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects. Journal of Tissue Engineering and Regenerative Medicine. (PMID:23038218)

Record type: Article

Abstract

Tissue engineering offers enormous potential for bone regeneration. Despite extensive in vitro and in vivo work, few strategies translate into clinical practice. This paper describes the combination of skeletal stem cells (SSCs) and impaction bone grafting (IBG) for the treatment of patients with bone defects associated with avascular necrosis of the femoral head. SSCs and milled allograft were impacted into necrotic bone in the femoral heads of four patients. Three patients remained asymptomatic at 22-44 month follow-up, but one patient has required total hip replacement (both hips). This has allowed retrieval of the femoral heads, which were analysed structurally and functionally by ?CT, histology and mechanical testing. A central channel of impacted bone was found in the femoral heads, which displayed a mature trabecular micro-architecture. The impacted bone was denser than the surrounding trabecular bone, as strong in compression and with histological micro-architecture comparable to that of trabecular bone. Analysis of the retrieved femoral head samples has demonstrated that this tissue-engineering strategy regenerates bone that is both structurally and functionally analogous to normal trabecular bone. SSCs, together with IBG, have proved an effective treatment for avascular necrosis of the femoral head and offer significant potential for the broader spectrum of bone defects. Copyright © 2012 John Wiley & Sons, Ltd.

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Published date: 5 October 2012
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 345742
URI: https://eprints.soton.ac.uk/id/eprint/345742
ISSN: 1932-6254
PURE UUID: df501426-76f4-4c78-8f9c-199fd7a53af8
ORCID for R.O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 29 Nov 2012 15:09
Last modified: 06 Jun 2018 12:53

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Contributors

Author: A. Aarvold
Author: J. O. Smith
Author: E.R. Tayton
Author: A.M.H. Jones
Author: J.I. Dawson
Author: S. Lanham
Author: A. Briscoe
Author: D.G. Dunlop
Author: R.O.C. Oreffo ORCID iD

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