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Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine

Record type: Article

Osteoarthritis (OA) is the most common form of arthritis worldwide and is the sixth leading cause of disability. It costs the UK economy approximately 1% of gross national product per annum. With an aging population, the cost of chronic conditions such as OA continues to rise. Historically, treatments for OA have been limited to painkillers, physiotherapy and joint injections. When these fail, patients are referred for joint replacement surgery. With the advent of tissue engineering strategies aimed at generating new bone and cartilage for repair of osteochondral defects, there has been considerable interest in exploiting these techniques to devise new treatments for OA. To date, little consideration has been given to the OA niche and attendant inflammatory milieu for any regenerative skeletal strategy. This review highlights the importance of understanding the osteoarthritic niche in order to modify existing tissue engineering and regenerative medicine strategies for the future treatment of OA.

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Citation

Williams, Emma L., Edwards, Christopher J., Cooper, Cyrus and Oreffo, Richard O.C. (2012) Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine Regenerative Medicine, 7, (4), pp. 551-570. (doi:10.2217/rme.12.34). (PMID:22817628).

More information

Published date: July 2012
Keywords: cytokines, inflammation, osteoarthritis, regenerative medicine, tissue engineering
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 345789
URI: http://eprints.soton.ac.uk/id/eprint/345789
ISSN: 1746-0751
PURE UUID: 7979bc74-fc76-4637-b480-55d3ae73cac3
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 03 Dec 2012 15:34
Last modified: 18 Jul 2017 05:07

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Contributors

Author: Emma L. Williams
Author: Cyrus Cooper

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