Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine
Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine
Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.
metabolomics, stem cells, biomaterials, mass spectrometry, regenerative medicine, titanium
1713-1724
McNamara, Laura E.
c5efd583-f6a3-4907-b357-1ccf4dba31cb
Sjöström, Terje
9d6734d1-6159-4b03-8e0f-504830018ddf
Meek, R.M. Dominic
d6875011-a538-4881-8170-baea6a02fac4
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Burgess, Karl E.V.
7eef15f0-15b2-4898-ac8a-bb5f49f8ff48
7 August 2012
McNamara, Laura E.
c5efd583-f6a3-4907-b357-1ccf4dba31cb
Sjöström, Terje
9d6734d1-6159-4b03-8e0f-504830018ddf
Meek, R.M. Dominic
d6875011-a538-4881-8170-baea6a02fac4
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Burgess, Karl E.V.
7eef15f0-15b2-4898-ac8a-bb5f49f8ff48
McNamara, Laura E., Sjöström, Terje, Meek, R.M. Dominic, Oreffo, Richard O.C., Su, Bo, Dalby, Matthew J. and Burgess, Karl E.V.
(2012)
Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine.
Journal of the Royal Society Interface, 9 (73), .
(doi:10.1098/rsif.2012.0169).
(PMID:22628210)
Abstract
Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.
This record has no associated files available for download.
More information
e-pub ahead of print date: 23 May 2012
Published date: 7 August 2012
Keywords:
metabolomics, stem cells, biomaterials, mass spectrometry, regenerative medicine, titanium
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 345793
URI: http://eprints.soton.ac.uk/id/eprint/345793
PURE UUID: 031e9a97-8b8b-4661-9a39-5ce196bbf544
Catalogue record
Date deposited: 03 Dec 2012 16:46
Last modified: 15 Mar 2024 03:04
Export record
Altmetrics
Contributors
Author:
Laura E. McNamara
Author:
Terje Sjöström
Author:
R.M. Dominic Meek
Author:
Bo Su
Author:
Matthew J. Dalby
Author:
Karl E.V. Burgess
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
