Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine


McNamara, Laura E., Sjöström, Terje, Meek, R.M. Dominic, Oreffo, Richard O.C., Su, Bo, Dalby, Matthew J. and Burgess, Karl E.V. (2012) Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine Journal of The Royal Society Interface, 9, (73), pp. 1713-1724. (doi:10.1098/rsif.2012.0169). (PMID:22628210).

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Description/Abstract

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1098/rsif.2012.0169
Keywords: metabolomics, stem cells, biomaterials, mass spectrometry, regenerative medicine, titanium
Subjects:

Organisations: Human Development & Health
ePrint ID: 345793
Date :
Date Event
23 May 2012e-pub ahead of print
7 August 2012Published
Date Deposited: 03 Dec 2012 16:46
Last Modified: 17 Apr 2017 16:19
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/345793

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