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Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine

McNamara, Laura E., Sjöström, Terje, Meek, R.M. Dominic, Oreffo, Richard O.C., Su, Bo, Dalby, Matthew J. and Burgess, Karl E.V. (2012) Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine Journal of The Royal Society Interface, 9, (73), pp. 1713-1724. (doi:10.1098/rsif.2012.0169). (PMID:22628210).

Record type: Article

Abstract

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

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e-pub ahead of print date: 23 May 2012
Published date: 7 August 2012
Keywords: metabolomics, stem cells, biomaterials, mass spectrometry, regenerative medicine, titanium
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 345793
URI: http://eprints.soton.ac.uk/id/eprint/345793
PURE UUID: 031e9a97-8b8b-4661-9a39-5ce196bbf544
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 03 Dec 2012 16:46
Last modified: 18 Jul 2017 05:07

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Contributors

Author: Laura E. McNamara
Author: Terje Sjöström
Author: R.M. Dominic Meek
Author: Bo Su
Author: Matthew J. Dalby
Author: Karl E.V. Burgess

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